Isoniazid preventive therapy in HIV infected children on antiretroviral therapy living in a high tuberculosis prevalence area a randomized controlled trial

Tuberculosis (TB) and HIV are dual epidemics and a public health crisis in Southern Africa. An estimated 2.5 million children are living with HIV, of which 2.3 million live in Sub-Saharan Africa, with an estimated 230 000 child deaths from AIDS. In 2010 there were an estimated 8 million incident cases of tuberculosis (TB) globally, 1.2 million amongst people living with HIV. Over 1 million TB related deaths occurred, a third of which occurred amongst people living with HIV.[4] The African region accounts for 26% of the global TB burden and 82% of the TB cases among people living with HIV. TB and HIV are a deleterious combination. TB is a common cause of acute and chronic respiratory disease and a leading cause of death amongst HIV infected children in TB endemic areas.

Grantor dc:publisher.institution

Department of Paediatrics and Child Health

Year dc:date.issued

2012

Author dc:creator

• Gray, Diane Margaret

Advisor dc:contributor.advisor

• Zar, Heather

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/10538

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/10538