{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/10468"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/10468","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Retrospective analysis of outcomes in the programme of fast-tracking of antiretroviral therapy for patients admitted to a palliative care centre after diagnosis of opportunistic infections","abstract":"Although national guidelines in South Africa recommend starting antiretroviral therapy (ART) mainly to outpatients with WHO stage four disease and/or CD4 count of 200 cells/uL, immediate ART initiation after opportunistic infection (OI) treatment in the inpatient wards at several international sites has been shown to reduce the adverse outcomes of AIDS progression and death. Current South African policies of discharging patients after hospital admission for management of OIs for follow up and initiation of ART at ARV clinics result in poor patient outcomes as described by reports from South Africa. In contrast, this study demonstrates the feasibility and effectiveness, under routine programme conditions, of a rapid, supervised inpatient ART initiation. Further research is needed to reduce the high rate of early mortality among patients with advanced HIV disease.","abstract_html":"Although national guidelines in South Africa recommend starting antiretroviral therapy (ART) mainly to outpatients with WHO stage four disease and/or CD4 count of 200 cells/uL, immediate ART initiation after opportunistic infection (OI) treatment in the inpatient wards at several international sites has been shown to reduce the adverse outcomes of AIDS progression and death. Current South African policies of discharging patients after hospital admission for management of OIs for follow up and initiation of ART at ARV clinics result in poor patient outcomes as described by reports from South Africa. In contrast, this study demonstrates the feasibility and effectiveness, under routine programme conditions, of a rapid, supervised inpatient ART initiation. Further research is needed to reduce the high rate of early mortality among patients with advanced HIV disease.","abstract_has_math":false,"creators":["Edwin, Christina"],"institution":"Department of Public Health and Family Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Gwyther, Liz"],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-22T22:23:27Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/10468","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Gwyther, Liz"]},{"key":"dc:creator","label":"Author","values":["Edwin, Christina"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-12-29T04:58:54Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-12-29T04:58:54Z"]},{"key":"dc:date.issued","label":"Date","values":["2010"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Public Health and Family Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MPhil"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/10468"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references (leaves 60-64)."]},{"key":"dc:description.abstract","label":"Abstract","values":["Although national guidelines in South Africa recommend starting antiretroviral therapy (ART) mainly to outpatients with WHO stage four disease and/or CD4 count of 200 cells/uL, immediate ART initiation after opportunistic infection (OI) treatment in the inpatient wards at several international sites has been shown to reduce the adverse outcomes of AIDS progression and death. Current South African policies of discharging patients after hospital admission for management of OIs for follow up and initiation of ART at ARV clinics result in poor patient outcomes as described by reports from South Africa. In contrast, this study demonstrates the feasibility and effectiveness, under routine programme conditions, of a rapid, supervised inpatient ART initiation. Further research is needed to reduce the high rate of early mortality among patients with advanced HIV disease."]},{"key":"dc:title","label":"Title","values":["Retrospective analysis of outcomes in the programme of fast-tracking of antiretroviral therapy for patients admitted to a palliative care centre after diagnosis of opportunistic infections"]}]}],"canonical_facts":{"dc:contributor.advisor":["Gwyther, Liz"],"dc:creator":["Edwin, Christina"],"dc:date.accessioned":["2014-12-29T04:58:54Z"],"dc:date.available":["2014-12-29T04:58:54Z"],"dc:date.issued":["2010"],"dc:description":["Includes bibliographical references (leaves 60-64)."],"dc:description.abstract":["Although national guidelines in South Africa recommend starting antiretroviral therapy (ART) mainly to outpatients with WHO stage four disease and/or CD4 count of 200 cells/uL, immediate ART initiation after opportunistic infection (OI) treatment in the inpatient wards at several international sites has been shown to reduce the adverse outcomes of AIDS progression and death. Current South African policies of discharging patients after hospital admission for management of OIs for follow up and initiation of ART at ARV clinics result in poor patient outcomes as described by reports from South Africa. In contrast, this study demonstrates the feasibility and effectiveness, under routine programme conditions, of a rapid, supervised inpatient ART initiation. Further research is needed to reduce the high rate of early mortality among patients with advanced HIV disease."],"dc:identifier.uri":["http://hdl.handle.net/11427/10468"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Public Health and Family Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Retrospective analysis of outcomes in the programme of fast-tracking of antiretroviral therapy for patients admitted to a palliative care centre after diagnosis of opportunistic infections"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MPhil"]},"updated_at":"2026-07-22T22:23:27Z"}