Analysis of desmoplakin in arrythmogenic right ventricular cardiomyopathy

It has been shown that all forms of cardiomyopathy, including the dilated, hypertrophic, restrictive, and right ventricular arrhythmogenic forms, are found in African populations. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare muscle disease characterised by fibrofatty replacement of the right ventricular myocardium, leading to electrical instability and eventual heart failure. Dilated cardiomyopathy (DCM) is a disease characterised by a reduction in ventricular wall thickness which leads to reduced contractility and impaired ventricular function. Mutations that cause ARVC have been reported in five desmosomal and three non-desmosomal genes.

Grantor dc:publisher.institution

Department of Medicine

Year dc:date.issued

2010

Author dc:creator

• Fish, Maryam

Advisors dc:contributor.advisor

• Mayosi, Bongani
• Shaboodien, Gasnat

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/10466

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/10466