Utility of newer technologies for the diagnosis of active and latent tuberculosis
type: CreativeWork
description: Since the 1800s the tuberculin skin test (TST) has been the only available test for latent tuberculosis (LTBI). Recently, interferon-gamma release assays (IGRAs) have been developed which are based upon the responses of peripheral blood effector cells to M.tb-specific antigens [early secretory antigenic target -6 (ESAT-6) and culture filtrate protein (CFP10)]. Discordance between the TST and IGRAs has been well documented but remains largely unexplained.
abstract: Since the 1800s the tuberculin skin test (TST) has been the only available test for latent tuberculosis (LTBI). Recently, interferon-gamma release assays (IGRAs) have been developed which are based upon the responses of peripheral blood effector cells to M.tb-specific antigens [early secretory antigenic target -6 (ESAT-6) and culture filtrate protein (CFP10)]. Discordance between the TST and IGRAs has been well documented but remains largely unexplained.
author: Cashmore, Tamaryn Jane
language: eng
date published: 2010
date modified: 2026-07-22T22:22:46Z
provider: University of Cape Town
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Department of Medicine

PropertyValue
property ID: Handle
value: http://hdl.handle.net/11427/10221