Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer

Tobacco smoking is a major risk factor in the development of oesophageal squamous cell carcinoma (OSCC). Benzo[a]pyrene (BaP) is a tobacco smoke procarcinogen that is metabolically activated into the carcinogenic benzo[a]pyrene diol-epoxide (BPDE) by the CYP1 family of cytochrome P450 enzymes. BaP is a ligand for the aryl hydrocarbon receptor (AhR) which activates CYP1 gene transcription. Polymorphisms in these genes affect enzyme activity and therefore BaP bioactivation.

Grantor dc:publisher.institution

Division of Medical Biochemistry

Year dc:date.issued

2011

Author dc:creator

• Bick, Alexis J

Advisor dc:contributor.advisor

• Parker, M Iqbal

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/10124

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/10124