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The studies in this thesis provided evidence for the physiological relevance of the optimal cerebral perfusion pressure paradigm, CPPopt, and further demonstrated its potential, alongside CPP-oriented therapy, as clinical tools. Two novel indices were developed: UBP, the compensatory reserve upper breakpoint, which may serve as an indicator for the trigger of life saving physiological mechanisms, and RAMP, reflective of the relationship between intracranial pressure and cerebral blood flow velocity pulse amplitudes. Finally, a dependency between craniospinal compliance and the frequency at which it is calculated was discovered, and deep learning models showed potential for predicting intracranial pressure non-invasively. The results of these studies, several of which have been published, suggest increased potential for individualised treatment paradigms for the brain injured patient. 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