Genetic Determinants of Human Susceptibility to Infections: A Multi-faceted Exome-based Analysis in the UK Biobank
type: CreativeWork
description: Genetic factors play a crucial role in determining susceptibility to infections and shaping immune responses, yet this area remains understudied in genome-wide association studies (GWAS), particularly in the context of exome sequencing. This thesis begins with a comprehensive literature review, which explores how advancements in sequencing technologies and analytical methods have revolutionized our understanding of genetic contributions to complex traits, including infectious diseases. The literature review provides a critical foundation for the thesis by examining the methodological intricacies of GWAS and their applications in infectious disease research. It highlights the importance of complementary statistical approaches, such as fine-mapping and colocalisation analyses, in refining GWAS findings and uncovering causal variants. The review also delves into the emerging field of pharmacogenomics, setting the stage for investigating genetic influences on drug responses, particularly in the context of infectious diseases. Building on this comprehensive background, the thesis addresses existing knowledge gaps through three interconnected studies utilising UK Biobank datasets. These studies investigate the relationships between genetics, exomes, and immune responses, focusing on serological antibody responses to common pathogens, broader phenotypic effects of infection-related genetic variants, and pharmacogenetic interactions in COVID-19 outcomes. The first research chapter employed whole exome analysis to identify 30 genetic variants independently associated with immune responses to six common pathogens. Fine-mapping revealed 30 causal exonic variants, demonstrating the potential of exome sequencing in uncovering rare variants related to infection-related traits. The second research chapter conducted a phenome-wide association study (PheWAS), revealing 304 significant associations between 25 genetic variants and 98 diverse phenotypic traits. Colocalisation analyses …
abstract: Genetic factors play a crucial role in determining susceptibility to infections and shaping immune responses, yet this area remains understudied in genome-wide association studies (GWAS), particularly in the context of exome sequencing. This thesis begins with a comprehensive literature review, which explores how advancements in sequencing technologies and analytical methods have revolutionized our understanding of genetic contributions to complex traits, including infectious diseases. The literature review provides a critical foundation for the thesis by examining the methodological intricacies of GWAS and their applications in infectious disease research. It highlights the importance of complementary statistical approaches, such as fine-mapping and colocalisation analyses, in refining GWAS findings and uncovering causal variants. The review also delves into the emerging field of pharmacogenomics, setting the stage for investigating genetic influences on drug responses, particularly in the context of infectious diseases. Building on this comprehensive background, the thesis addresses existing knowledge gaps through three interconnected studies utilising UK Biobank datasets. These studies investigate the relationships between genetics, exomes, and immune responses, focusing on serological antibody responses to common pathogens, broader phenotypic effects of infection-related genetic variants, and pharmacogenetic interactions in COVID-19 outcomes. The first research chapter employed whole exome analysis to identify 30 genetic variants independently associated with immune responses to six common pathogens. Fine-mapping revealed 30 causal exonic variants, demonstrating the potential of exome sequencing in uncovering rare variants related to infection-related traits. The second research chapter conducted a phenome-wide association study (PheWAS), revealing 304 significant associations between 25 genetic variants and 98 diverse phenotypic traits. Colocalisation analyses …
author: Zhu, Zhengyang
language: eng
keywords: antibody, exome, genomic, GWAS, infectious disease
license: https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/d9865567-99ec-4a40-a887-6181602c72e0/download
license: http://purl.org/NET/rdflicense/allrightsreserved
date published: 2024-10-21
date modified: 2026-07-22T22:24:23Z
provider: Cambridge University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Cambridge

PropertyValue
property ID: DOI
value: 10.17863/CAM.120507