Mathematical Modelling of Brain Haemodynamics and Pressure-Volume Compensation
type: CreativeWork
description: Traumatic brain injury (TBI) is a major global health issue with diverse demographics and a dynamic clinical profile. Modern care of a pathology with such variabilities involves individualised treatment, which requires an accurate understanding of pressure-volume interactions inside the cranium. This thesis used a hydrodynamic model representing the circulation of cerebral fluids to investigate the relationships between intracranial pressure (ICP) and cerebral blood volume (CBV) changes. The effects of these relationships on the performance of indices describing vascular dynamics were also examined. The background of this project is discussed in Chapters 1 to 4 of this thesis. Chapter 1 provides a description of the anatomical and physiological aspects of the cerebrospinal space, including the circulation of cerebral fluids and the pressure-volume interactions among different compartments within the cranium. Chapter 2 introduces the pathophysiology of cerebral hydrodynamics in patients with TBI, and the important role of neuro-monitoring in its management. Chapter 3 specifies the aims and hypotheses of this project, while Chapter 4 includes a literature review of previous modelling work in cerebral blood flow (CBF) and cerebrospinal fluid (CSF) dynamics. In this project, a computer programme was written to create an implementation of the electrical equivalence of the hydrodynamic model. With a set of model parameters and imported data, the programme was used to simulate the pressures and flows of fluids in different intracranial compartments. Details of the programme were specified in Chapter 5, while experiments with the model were included in Chapters 6 to 9. In Chapter 6, the validity of an existing model was tested with a series of experiments simulating various clinical phenomena. The simulations include pathophysiological features caused by dynamic variations in cerebrovascular properties, as well as prolonged changes in CBV. In Chapter 7, the existing model w…
abstract: Traumatic brain injury (TBI) is a major global health issue with diverse demographics and a dynamic clinical profile. Modern care of a pathology with such variabilities involves individualised treatment, which requires an accurate understanding of pressure-volume interactions inside the cranium. This thesis used a hydrodynamic model representing the circulation of cerebral fluids to investigate the relationships between intracranial pressure (ICP) and cerebral blood volume (CBV) changes. The effects of these relationships on the performance of indices describing vascular dynamics were also examined. The background of this project is discussed in Chapters 1 to 4 of this thesis. Chapter 1 provides a description of the anatomical and physiological aspects of the cerebrospinal space, including the circulation of cerebral fluids and the pressure-volume interactions among different compartments within the cranium. Chapter 2 introduces the pathophysiology of cerebral hydrodynamics in patients with TBI, and the important role of neuro-monitoring in its management. Chapter 3 specifies the aims and hypotheses of this project, while Chapter 4 includes a literature review of previous modelling work in cerebral blood flow (CBF) and cerebrospinal fluid (CSF) dynamics. In this project, a computer programme was written to create an implementation of the electrical equivalence of the hydrodynamic model. With a set of model parameters and imported data, the programme was used to simulate the pressures and flows of fluids in different intracranial compartments. Details of the programme were specified in Chapter 5, while experiments with the model were included in Chapters 6 to 9. In Chapter 6, the validity of an existing model was tested with a series of experiments simulating various clinical phenomena. The simulations include pathophysiological features caused by dynamic variations in cerebrovascular properties, as well as prolonged changes in CBV. In Chapter 7, the existing model w…
author: Chu, Ka Hing
language: eng
keywords: Cerebral Haemodynamics, Mathematical Modelling, Traumatic Brain Injury
license: https://www.repository.cam.ac.uk/bitstreams/128ff4aa-8206-418b-94ee-84b8b8e50b0f/download
license: https://www.rioxx.net/licenses/all-rights-reserved/
date published: 2024-02-29
date modified: 2026-07-24T01:33:25Z
provider: Cambridge University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Cambridge

PropertyValue
property ID: DOI
value: 10.17863/CAM.111993