THE EXPLORATION OF THE VALIDITY OF QUANTITATIVE 2-DEOXY-2-[FLUORINE-18] FLUORO-D-GLUCOSE (18F-FDG) POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY (PET/CT) TO ASSESS LUNG INFLAMMATION
type: CreativeWork
description: Lung diseases are one of the leading causes of death in the UK; responsible for 20% of all deaths each year. Inflammation is thought to be an important driver of the pathogenesis and progression of several lung diseases. Positron emission tomography/computed tomography (PET/CT) is an imaging modality capable of providing functional and molecular imaging through detection of trace quantities of a radioactive tracer. 18F-FDG is the most widely available tracer and in several small studies has been used to investigate diffuse lung diseases such as chronic obstructive pulmonary disease (COPD). These studies rely on quantification of the PET image. Static acquisitions provide information on the biodistribution of the tracer at a single time point after administration, the standardised uptake value (SUV) is the most widely used measure of 18F-FDG uptake. Dynamic acquisitions provide information on the spatial and temporal distribution of the tracer; linear and non-linear modelling techniques allow estimation of the metabolic rate of 18F-FDG in the lung. Previous studies have used a linear method called Patlak graphical analysis, whilst non-linear compartmental models have been used more recently to estimate metabolism. However, these contending measures of pulmonary 18F-FDG uptake, which are putative biomarkers of lung inflammation, have so far been disparately applied. Further, there is nascent understanding that these imaging endpoints are affected by pulmonary air and blood volume; the importance of this effect will likely depend on the disease and its severity. These issues are exacerbated by the presence of respiratory motion and the low signal- to-noise ratio achieved in PET studies. This has led to questions regarding the utility of quantitative 18F-FDG PET to assess lung inflammation. In this work, prospective and retrospective clinical studies were used to assess the clinical, biological and technical validity of 18F-FDG PET imaging endpoints in several clinicall…
abstract: Lung diseases are one of the leading causes of death in the UK; responsible for 20% of all deaths each year. Inflammation is thought to be an important driver of the pathogenesis and progression of several lung diseases. Positron emission tomography/computed tomography (PET/CT) is an imaging modality capable of providing functional and molecular imaging through detection of trace quantities of a radioactive tracer. 18F-FDG is the most widely available tracer and in several small studies has been used to investigate diffuse lung diseases such as chronic obstructive pulmonary disease (COPD). These studies rely on quantification of the PET image. Static acquisitions provide information on the biodistribution of the tracer at a single time point after administration, the standardised uptake value (SUV) is the most widely used measure of 18F-FDG uptake. Dynamic acquisitions provide information on the spatial and temporal distribution of the tracer; linear and non-linear modelling techniques allow estimation of the metabolic rate of 18F-FDG in the lung. Previous studies have used a linear method called Patlak graphical analysis, whilst non-linear compartmental models have been used more recently to estimate metabolism. However, these contending measures of pulmonary 18F-FDG uptake, which are putative biomarkers of lung inflammation, have so far been disparately applied. Further, there is nascent understanding that these imaging endpoints are affected by pulmonary air and blood volume; the importance of this effect will likely depend on the disease and its severity. These issues are exacerbated by the presence of respiratory motion and the low signal- to-noise ratio achieved in PET studies. This has led to questions regarding the utility of quantitative 18F-FDG PET to assess lung inflammation. In this work, prospective and retrospective clinical studies were used to assess the clinical, biological and technical validity of 18F-FDG PET imaging endpoints in several clinicall…
author: Vass, Laurence
language: eng
keywords: PET, Lung, Inflammation
license: https://www.repository.cam.ac.uk/bitstreams/d3e47047-2f8c-40bb-a0cf-d3c62f5653da/download
license: https://creativecommons.org/licenses/by/4.0/
date published: 2020-11-16
date modified: 2026-07-22T22:23:56Z
provider: Cambridge University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Cambridge

PropertyValue
property ID: DOI
value: 10.17863/CAM.66722