{"id":{"repo_id":"cambridge","oai_identifier":"oai:www.repository.cam.ac.uk:1810/297932"},"canonical_url":"https://search.dev.ndltd.org/etd/cambridge/oai:www.repository.cam.ac.uk:1810/297932","repository":{"repo_id":"cambridge","name":"Cambridge University","base_url":"https://api.repository.cam.ac.uk/server/oai/request"},"display":{"title":"Immunological markers in hairy-cell leukaemia","abstract":"The dissertation consists of six chapters. Chapter 1 presents a brief introduction on immunological markers. Chapter 2 describes the discovery of a previously unrecognised marker in hairy-cell leukaemia (HCL), a receptor for IgM. The rosette method used to reveal this receptor, and the conditions affecting rosette formation are described. A kinetic study of this receptor is used to provide a measure of membrane turnover in HCL. The distribution of the IgM receptor among normal and malignant haemic cells is investigated. Chapter 3 considers a variety of other immunological markers in HCL. Previous controversy in the literature concerning the presence of a receptor for complement on hairy cells is resolved and new information is provided about the presence of other markers on hairy cells. Chapter 4 presents experiments designed to investigate conflicting evidence regarding the nature of the hairy cell. Monocytic properties are measured and weighed against features of hairy cells which align them with the B-lymphocyte series. The presence of intrinsic surface immunoglobulin (Sig) is used as evidence for the B-cell nature of HCL. The results obtained showing only IgG on the surface of some cases of HCL, and multiple heavy chain isotypes on others, provide a solution to the confused literature regarding the presence of SIg on hairy cells. Two unusual cases of immunoproliferative diseases are extensively investigated in Chapter 5 in order to demonstrate some of the problems associated with immunological marker studies. Chapter 6 reviews the thesis and draws conclusions about the nosology of HCL. A possible position for HCL in schemes of B-cell differentiation is given. Several papers of unconnected work submitted during the period of research for the dissertation are also included for consideration by the Examiners.","abstract_html":"The dissertation consists of six chapters. Chapter 1 presents a brief introduction on immunological markers. Chapter 2 describes the discovery of a previously unrecognised marker in hairy-cell leukaemia (HCL), a receptor for IgM. The rosette method used to reveal this receptor, and the conditions affecting rosette formation are described. A kinetic study of this receptor is used to provide a measure of membrane turnover in HCL. The distribution of the IgM receptor among normal and malignant haemic cells is investigated. Chapter 3 considers a variety of other immunological markers in HCL. Previous controversy in the literature concerning the presence of a receptor for complement on hairy cells is resolved and new information is provided about the presence of other markers on hairy cells. Chapter 4 presents experiments designed to investigate conflicting evidence regarding the nature of the hairy cell. Monocytic properties are measured and weighed against features of hairy cells which align them with the B-lymphocyte series. The presence of intrinsic surface immunoglobulin (Sig) is used as evidence for the B-cell nature of HCL. The results obtained showing only IgG on the surface of some cases of HCL, and multiple heavy chain isotypes on others, provide a solution to the confused literature regarding the presence of SIg on hairy cells. Two unusual cases of immunoproliferative diseases are extensively investigated in Chapter 5 in order to demonstrate some of the problems associated with immunological marker studies. Chapter 6 reviews the thesis and draws conclusions about the nosology of HCL. A possible position for HCL in schemes of B-cell differentiation is given. Several papers of unconnected work submitted during the period of research for the dissertation are also included for consideration by the Examiners.","abstract_has_math":false,"creators":["Burns, Gordon Frood"],"institution":"University of Cambridge","degree_name":"Doctor of Philosophy (PhD)","degree_level":"Doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1979,"date_issued":"1979-02-27","date_published":"1979-02-27","updated_at":"2026-07-24T01:33:23Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":["https://www.repository.cam.ac.uk/bitstreams/a813080f-719f-43bc-a6be-1c76d4126abf/download","https://www.rioxx.net/licenses/all-rights-reserved/"],"identifier_entries":[]},"links":{"outbound_url":"https://doi.org/10.17863/CAM.44986","outbound_label":"DOI","outbound_source":"dc:identifier.doi"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.sponsor","label":"Sponsor","values":["Digitisation of this thesis was sponsored by Arcadia Fund, a charitable fund of Lisbet Rausing and Peter Baldwin"]},{"key":"dc:creator","label":"Author","values":["Burns, Gordon Frood"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["1979-02-27"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cambridge"]},{"key":"dc:relation.isreferencedby.uri","label":"Dc Relation Isreferencedby URI","values":["https://www.repository.cam.ac.uk/handle/1810/297932"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Doctor of Philosophy (PhD)"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["https://www.repository.cam.ac.uk/bitstreams/a813080f-719f-43bc-a6be-1c76d4126abf/download","https://www.rioxx.net/licenses/all-rights-reserved/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["10.17863/CAM.44986"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://www.repository.cam.ac.uk/bitstreams/f449f365-783b-442f-8028-6c5eec117b44/download"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The dissertation consists of six chapters. 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The presence of intrinsic surface immunoglobulin (Sig) is used as evidence for the B-cell nature of HCL. The results obtained showing only IgG on the surface of some cases of HCL, and multiple heavy chain isotypes on others, provide a solution to the confused literature regarding the presence of SIg on hairy cells. Two unusual cases of immunoproliferative diseases are extensively investigated in Chapter 5 in order to demonstrate some of the problems associated with immunological marker studies. Chapter 6 reviews the thesis and draws conclusions about the nosology of HCL. A possible position for HCL in schemes of B-cell differentiation is given. 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A kinetic study of this receptor is used to provide a measure of membrane turnover in HCL. The distribution of the IgM receptor among normal and malignant haemic cells is investigated. Chapter 3 considers a variety of other immunological markers in HCL. Previous controversy in the literature concerning the presence of a receptor for complement on hairy cells is resolved and new information is provided about the presence of other markers on hairy cells. Chapter 4 presents experiments designed to investigate conflicting evidence regarding the nature of the hairy cell. Monocytic properties are measured and weighed against features of hairy cells which align them with the B-lymphocyte series. The presence of intrinsic surface immunoglobulin (Sig) is used as evidence for the B-cell nature of HCL. The results obtained showing only IgG on the surface of some cases of HCL, and multiple heavy chain isotypes on others, provide a solution to the confused literature regarding the presence of SIg on hairy cells. Two unusual cases of immunoproliferative diseases are extensively investigated in Chapter 5 in order to demonstrate some of the problems associated with immunological marker studies. Chapter 6 reviews the thesis and draws conclusions about the nosology of HCL. A possible position for HCL in schemes of B-cell differentiation is given. 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