{"id":{"repo_id":"cambridge","oai_identifier":"oai:www.repository.cam.ac.uk:1810/294026"},"canonical_url":"https://search.dev.ndltd.org/etd/cambridge/oai:www.repository.cam.ac.uk:1810/294026","repository":{"repo_id":"cambridge","name":"Cambridge University","base_url":"https://api.repository.cam.ac.uk/server/oai/request"},"display":{"title":"Comparative functional analysis of the atypical Notch ligands DLK1 and DLK2 in vertebrate development","abstract":"DLK1 and DLK2 are vertebrate specific non-canonical Notch ligands. Dlk1 is imprinted throughout murine development [76] but selectively loses its imprint in the postnatal neurogenic niche by an unknown mechanism [78]. Possessing both secreted and membrane-tethered isoforms[212, 211], DLK1 plays critical roles in a wide range of developmental processes and is implicated in several diseases, including obesity and cancer[35, 241]. Apart from a few exceptions[78], in the majority of processes, the precise roles and relative contributions of membrane-bound and secreted DLK1 are unknown . DLK2 is a related gene with homology to DLK1 [108, 49]; however virtually nothing is known about it. Preliminary data from the Ferguson-Smith lab suggests that it is involved in neurogenesis in the Zebrafish. This project investigates the role that DLK2 plays in wild-type mice and compares the gene to DLK1.","abstract_html":"DLK1 and DLK2 are vertebrate specific non-canonical Notch ligands. Dlk1 is imprinted throughout murine development [76] but selectively loses its imprint in the postnatal neurogenic niche by an unknown mechanism [78]. Possessing both secreted and membrane-tethered isoforms[212, 211], DLK1 plays critical roles in a wide range of developmental processes and is implicated in several diseases, including obesity and cancer[35, 241]. Apart from a few exceptions[78], in the majority of processes, the precise roles and relative contributions of membrane-bound and secreted DLK1 are unknown . DLK2 is a related gene with homology to DLK1 [108, 49]; however virtually nothing is known about it. Preliminary data from the Ferguson-Smith lab suggests that it is involved in neurogenesis in the Zebrafish. This project investigates the role that DLK2 plays in wild-type mice and compares the gene to DLK1.","abstract_has_math":false,"creators":["Ashcroft, Alexandra"],"institution":"University of Cambridge","degree_name":"Master of Science (MSc)","degree_level":"Masters","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Ferguson-Smith, Anne"],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-07-12","date_published":"2019-07-12","updated_at":"2026-07-22T22:24:23Z","subjects":["DLK1","DLK2","mouse model","developmental biology","zebrafish","mice","evo-devo"],"languages":["en"],"rights":[],"rights_urls":["https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/31f65935-0306-4755-893c-ed2277d272f8/download","https://www.rioxx.net/licenses/all-rights-reserved/"],"identifier_entries":[]},"links":{"outbound_url":"https://doi.org/10.17863/CAM.41135","outbound_label":"DOI","outbound_source":"dc:identifier.doi"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Ferguson-Smith, Anne"]},{"key":"dc:contributor.sponsor","label":"Sponsor","values":["My work was funded by a Wellcome Trust studentship and a Lander studentship from my college."]},{"key":"dc:creator","label":"Author","values":["Ashcroft, Alexandra"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2019-07-12"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cambridge"]},{"key":"dc:relation.isreferencedby.uri","label":"Dc Relation Isreferencedby URI","values":["https://www.repository.cam.ac.uk/handle/1810/294026"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Master of Science (MSc)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["DLK1","DLK2","mouse model","developmental biology","zebrafish","mice","evo-devo"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/31f65935-0306-4755-893c-ed2277d272f8/download","https://www.rioxx.net/licenses/all-rights-reserved/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["10.17863/CAM.41135"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/92b23dd4-da49-4583-b561-639eeaf5b4b3/download"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["DLK1 and DLK2 are vertebrate specific non-canonical Notch ligands. 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