Humoral alloimmunity in cardiac allograft rejection

Although the short-term outcomes of solid allograft survival have improved substantially over the last few decades, there has been no significant improvement in long-term survival of solid allografts. This thesis presents the initial characterisation of alloantibody mediated rejection in a murine heart transplant model, with particular focus on the impact of the different phases of the humoral alloimmune response (follicular or germinal centre) on graft rejection.

Name dc:type.qualificationname

Doctor of Philosophy (PhD)

Level dc:type.qualificationlevel

Doctoral

Grantor dc:publisher.institution

University of Cambridge

Year dc:date.issued

2019

Author dc:creator

• Alsughayyir, Jawaher

Advisor dc:contributor.advisor

• Pettigrew, Gavin

• Transplantation
• antibody-mediated rejection
• rejection
• organ transplantation

Licence

• https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/43deebad-de30-47a0-aff8-a258affd45b7/download
• https://www.rioxx.net/licenses/all-rights-reserved/

Language dc:language

en

DOI dc:identifier.doi

https://doi.org/10.17863/CAM.34281

OAI identifier oai:identifier

oai:www.repository.cam.ac.uk:1810/286971