The application of immobilized reagents and scavengers to multi-step organic synthesis: a total synthesis of epothilone C.

Chapter one provides an introduction to solid-phase synthesis techniques including an account of the development and integration of solid-supported reagents within multistep synthesis as a background to the project. Chapter two introduces the epothilone natural products including an explanation of the biological properties possessed by these molecules. Chapter three presents a review of previous total syntheses of the natural epothilones. Chapter four describes the results and discussion for a new total synthesis of epothilone C that applied immobilized reagents and scavengers. Chapter five provides a formal report of the experimental procedures for chapter four.

Name dc:type.qualificationname

Doctor of Philosophy (PhD)

Level dc:type.qualificationlevel

Doctoral

Grantor dc:publisher.institution

University of Cambridge

Year dc:date.issued

2003

Author dc:creator

• Storer, Robert Ian

Licence

• https://apollo8-f-pro.lib.cam.ac.uk/bitstreams/fbadd43c-3697-4d1a-aa8d-da0be781cb01/download
• https://www.rioxx.net/licenses/all-rights-reserved/

Language dc:language

eng

DOI dc:identifier.doi

https://doi.org/10.17863/CAM.11636

OAI identifier oai:identifier

oai:www.repository.cam.ac.uk:1810/265458