Poroelastic Finite Element Analysis of a Heterogeneous Articular Cartilage Explant Under Dynamic Compression in ABAQUS

<p> <p>A poroelastic finite element model of a heterogeneous articular cartilage disc was</p> <p>created to examine the tissue response to low amplitude (± 2% strain), low</p> <p>frequency (0.1 Hz) dynamic unconfined compression (UCC). A strong correlation</p> <p>has been made between the relative fluid velocity and stimulation of</p> <p>glycosaminoglycan synthesis. A contour plot of the model shows the relative fluid</p> <p>velocity during compression exceeds a trigger value of 0.25 μm/s at the radial</p> <p>periphery. Dynamic UCC biochemical results have also reported a higher</p> <p>glycosaminoglycan content in this region versus that of day 0 specimens. Fluid</p> <p>velocity was also found not to be the dominant physical mechanism that</p> <p>stimulates collagen synthesis; the heterogeneity of the fluid velocity contour plot</p> <p>conflicts with the homogeneous collagen content from the biochemical results. It</p> <p>was also found that a Tresca (shear) stress trigger of 0.07 MPa could provide</p> <p>minor stimulation of glycosaminoglycan synthesis. A feasibility study on</p> <p>modeling a heterogeneous disc was conducted and found convergence issues with</p> <p>the jump in properties from the superficial to middle layers of the disc. It is</p> <p>believed that the superficial layer contains material properties that allow the tissue</p> <p>to absorb much of the compressive strain, which in turn increases pressure and</p> <p>causes convergence issues in ABAQUS. The findings in this thesis may help</p> <p>guide the development of a growth and remodeling routine for articular cartilage.</p> </p>

Name thesis:degree_name

MS in Mechanical Engineering

Discipline thesis:degree_discipline

Mechanical Engineering

Year dc:date.available

2011

Author dc:creator

• Kam, Kelsey Kiyo

Contributors dc:contributor

• Stephen M. Klisch

• poroelastic
• FEA
• dynamic unconfined compression
• fluid velocity
• articular cartilage
• Biomechanical Engineering

Identifier

10.15368/theses.2011.97

OAI identifier oai:identifier

oai:digitalcommons.calpoly.edu:theses-1575