Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection
type: CreativeWork
description: Human rhinovirus (HRV)-induced wheezing illnesses in early life are a major risk factor for subsequent asthma development, and may contribute to induction and progression of airway remodeling (AR) seen in the airways of asthmatic subjects. Thickening of the lamina reticularis is a component of AR that is due to increased deposition of matrix proteins by mesenchymal cells that are increased in asthmatic airways, although the origin(s) of these cells are unclear. We have shown that two different strains of HRV, alone and in the presence of transforming growth factor-β1, caused phenotypic changes in epithelial cells consistent with the process of epithelial to mesenchymal transition. Viral replication was not essential for phenotypic changes, which appear to be mediated, in part, via activation of mitogen activated protein kinase pathways, and via induction of the transcription factor, SLUG. These data support a role for HRV in the development and progression of AR.
abstract: Human rhinovirus (HRV)-induced wheezing illnesses in early life are a major risk factor for subsequent asthma development, and may contribute to induction and progression of airway remodeling (AR) seen in the airways of asthmatic subjects. Thickening of the lamina reticularis is a component of AR that is due to increased deposition of matrix proteins by mesenchymal cells that are increased in asthmatic airways, although the origin(s) of these cells are unclear. We have shown that two different strains of HRV, alone and in the presence of transforming growth factor-β1, caused phenotypic changes in epithelial cells consistent with the process of epithelial to mesenchymal transition. Viral replication was not essential for phenotypic changes, which appear to be mediated, in part, via activation of mitogen activated protein kinase pathways, and via induction of the transcription factor, SLUG. These data support a role for HRV in the development and progression of AR.
author: Minor, Danielle Marie
language: eng
keywords: Biophysics--Medical
date published: 2016
date modified: 2026-07-24T01:30:36Z
provider: University of Calgary
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Graduate Studies

PropertyValue
property ID: Handle
value: http://hdl.handle.net/11023/3332

PropertyValue
property ID: DOI
value: 10.11575/PRISM/25276