{"id":{"repo_id":"calgary","oai_identifier":"oai:ucalgary.scholaris.ca:11023/2659"},"canonical_url":"https://search.dev.ndltd.org/etd/calgary/oai:ucalgary.scholaris.ca:11023/2659","repository":{"repo_id":"calgary","name":"University of Calgary","base_url":"https://ucalgary.scholaris.ca/server/oai/request"},"display":{"title":"Cortical Excitability after Mild Traumatic Brain Injury in Children","abstract":"Introduction: Mild traumatic brain injury is frequently complicated by post-concussive syndrome. It is unknown why these symptoms persist, but recent research suggests that cortical excitability may play a role. Objectives: To determine if cortical excitability is different in pediatric mTBI, and if it correlates with symptom persistence. Methods:This was a cross-sectional controlled cohort study. Cortical excitability was measured using a variety of TMS paradigms in children with (symptomatic) and without (asymptomatic) persistent symptoms at one month post injury. The primary outcome measure was the corticalsilent period (cSP) (thought to represent GABAergic inhibition). Results: 57 children with mTBI (44% male; age 14.23 (SD:2.49)) and 28 controls were compared. cSP was similar between groups (F(2, 70)=0.53, p=0.591). There were no other significant group differences in cortical excitability. Conclusions: TMS was well tolerated in children with mTBI. Cortical excitability is similar to normal children at one-month following the injury.","abstract_html":"Introduction: Mild traumatic brain injury is frequently complicated by post-concussive syndrome. It is unknown why these symptoms persist, but recent research suggests that cortical excitability may play a role. Objectives: To determine if cortical excitability is different in pediatric mTBI, and if it correlates with symptom persistence. Methods:This was a cross-sectional controlled cohort study. Cortical excitability was measured using a variety of TMS paradigms in children with (symptomatic) and without (asymptomatic) persistent symptoms at one month post injury. The primary outcome measure was the corticalsilent period (cSP) (thought to represent GABAergic inhibition). Results: 57 children with mTBI (44% male; age 14.23 (SD:2.49)) and 28 controls were compared. cSP was similar between groups (F(2, 70)=0.53, p=0.591). There were no other significant group differences in cortical excitability. Conclusions: TMS was well tolerated in children with mTBI. Cortical excitability is similar to normal children at one-month following the injury.","abstract_has_math":false,"creators":["Seeger, Trevor"],"institution":"Graduate Studies","degree_name":"Master of Science (MSc)","degree_level":null,"degree_discipline":"Neuroscience","degree_department":null,"school":null,"contributors":[],"advisors":["Barlow, Karen","Kirton, Adam"],"committee_chairs":[],"committee_members":["Dunn, Jeff","Gallagher, Clare","Esser, Michael"],"year":2015,"date_issued":"2015-12-04","date_published":"2015-12-04","updated_at":"2026-07-24T01:30:27Z","subjects":["Neuroscience"],"languages":["eng"],"rights":["University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["http://dx.doi.org/10.11575/PRISM/25470"],"render_values":[{"text":"http://dx.doi.org/10.11575/PRISM/25470","href":"http://dx.doi.org/10.11575/PRISM/25470","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/11023/2659","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Barlow, Karen","Kirton, Adam"]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Dunn, Jeff","Gallagher, Clare","Esser, Michael"]},{"key":"dc:creator","label":"Author","values":["Seeger, Trevor"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-12-04T20:03:07Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-12-04T20:03:07Z"]},{"key":"dc:date.issued","label":"Date","values":["2015-12-04"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Calgary"]},{"key":"dc:type","label":"Dc Type","values":["master thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Neuroscience"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MSc)"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Calgary"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Neuroscience"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["http://dx.doi.org/10.11575/PRISM/25470"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11023/2659"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Introduction: Mild traumatic brain injury is frequently complicated by post-concussive syndrome. It is unknown why these symptoms persist, but recent research suggests that cortical excitability may play a role. Objectives: To determine if cortical excitability is different in pediatric mTBI, and if it correlates with symptom persistence. Methods:This was a cross-sectional controlled cohort study. Cortical excitability was measured using a variety of TMS paradigms in children with (symptomatic) and without (asymptomatic) persistent symptoms at one month post injury. The primary outcome measure was the corticalsilent period (cSP) (thought to represent GABAergic inhibition). Results: 57 children with mTBI (44% male; age 14.23 (SD:2.49)) and 28 controls were compared. cSP was similar between groups (F(2, 70)=0.53, p=0.591). There were no other significant group differences in cortical excitability. Conclusions: TMS was well tolerated in children with mTBI. Cortical excitability is similar to normal children at one-month following the injury."]},{"key":"dc:title","label":"Title","values":["Cortical Excitability after Mild Traumatic Brain Injury in Children"]}]}],"canonical_facts":{"dc:contributor.advisor":["Barlow, Karen","Kirton, Adam"],"dc:contributor.committeemember":["Dunn, Jeff","Gallagher, Clare","Esser, Michael"],"dc:creator":["Seeger, Trevor"],"dc:date.accessioned":["2015-12-04T20:03:07Z"],"dc:date.available":["2015-12-04T20:03:07Z"],"dc:date.issued":["2015-12-04"],"dc:description.abstract":["Introduction: Mild traumatic brain injury is frequently complicated by post-concussive syndrome. It is unknown why these symptoms persist, but recent research suggests that cortical excitability may play a role. Objectives: To determine if cortical excitability is different in pediatric mTBI, and if it correlates with symptom persistence. Methods:This was a cross-sectional controlled cohort study. Cortical excitability was measured using a variety of TMS paradigms in children with (symptomatic) and without (asymptomatic) persistent symptoms at one month post injury. The primary outcome measure was the corticalsilent period (cSP) (thought to represent GABAergic inhibition). Results: 57 children with mTBI (44% male; age 14.23 (SD:2.49)) and 28 controls were compared. cSP was similar between groups (F(2, 70)=0.53, p=0.591). There were no other significant group differences in cortical excitability. Conclusions: TMS was well tolerated in children with mTBI. Cortical excitability is similar to normal children at one-month following the injury."],"dc:identifier.doi":["http://dx.doi.org/10.11575/PRISM/25470"],"dc:identifier.uri":["http://hdl.handle.net/11023/2659"],"dc:language.iso":["eng"],"dc:publisher.institution":["University of Calgary"],"dc:rights":["University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission."],"dc:subject":["Neuroscience"],"dc:title":["Cortical Excitability after Mild Traumatic Brain Injury in Children"],"dc:type":["master thesis"],"thesis:degree_discipline":["Neuroscience"],"thesis:degree_name":["Master of Science (MSc)"],"thesis:institution_name":["University of Calgary"]},"updated_at":"2026-07-24T01:30:27Z"}