Complex Formation of Pb(II) with Cysteine, Penicillamine and N-acetylcysteine

The mechanism of lead poisoning and interest in metal toxicity has been a growing area of study since the late 1950s. In order to gain insight on how toxic metals behave physiologically, simple molecules can first be used to model the environments. Complex formation between Pb(II) and thiol-containing ligands D-penicillamine, L- cysteine and N-acetyl-L-cysteine were investigated in this study. The complexes formed were studied by 207Pb, 13C, 1H NMR, UV-Vis, ESI-MS, and X-ray absorption spectroscopy. The results of the study provide spectroscopic finger prints for Pb(II) coordination environments relevant to biological systems. The study revealed that small structural changes between each ligand, plays a large role in the manner at which they bind to the lead(II) centre.

Name thesis:degree_name

Master of Science (MSc)

Discipline thesis:degree_discipline

Chemistry

Grantor dc:publisher.institution

Graduate Studies

Year dc:date.issued

2014

Author dc:creator

• Sisombath, Natalie Sinh

Advisor dc:contributor.advisor

• Jalilehvand, Farideh

• Chemistry--Inorganic

Statement dc:rights

• University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.

Language dc:language.iso

eng

DOI

http://dx.doi.org/10.11575/PRISM/25383

OAI identifier oai:identifier

oai:ucalgary.scholaris.ca:11023/1722