Vascular Reactivity by Blood Oxygen Level Dependent Functional MRI in Cerebral Amyloid Angiopathy: Comparison with Alzheimer's Disease and Assessment of Longitudinal Change

Cerebral amyloid angiopathy (CAA) refers to the deposition of Abeta (Aβ) peptides in the brains small blood vessels leading to hemorrhagic stroke and cognitive impairment. Aβ is toxic to smooth muscle cells and impairs blood flow regulation. Reduced blood oxygen level dependent (BOLD) signal amplitude in response to a visual fMRI task has recently been implicated as a surrogate marker for impaired vascular reactivity in CAA. There have been no studies investigating how the BOLD amplitude changes in other Aβ diseases that present with CAA (Alzheimer’s disease (AD) or mild cognitive impairment (MCI)), or how it changes over time in CAA. BOLD amplitudes were lowest in CAA compared to controls but were not lower in MCI or AD. BOLD amplitudes decreased over 1-year in CAA but not in controls. These results provide more evidence for the use of BOLD amplitudes as a measure of impaired vascular reactivity in CAA.

Name thesis:degree_name

Master of Science (MSc)

Discipline thesis:degree_discipline

Neuroscience

Grantor dc:publisher.institution

Graduate Studies

Year dc:date.issued

2014

Author dc:creator

• Switzer, Aaron

Advisors dc:contributor.advisor

• Smith, Eric
• Goodyear, Bradley

• Neuroscience

Statement dc:rights

• University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.

Language dc:language.iso

eng

DOI

http://dx.doi.org/10.11575/PRISM/28634

OAI identifier oai:identifier

oai:ucalgary.scholaris.ca:11023/1687