Analisi dell’espressione della fosfoERK quale strumento di indagine per la caratterizzazione della sensibilità alle sostanze d’abuso in linee di ratti geneticamente selezionati
type: CreativeWork
description: Clinical studies indicate that genetically determined personality traits, such as sensation seeking and impulsivity, are associated with increased drug addiction liability. Thus, in spite of the fact that for instance a prolonged ethanol exposure is an essential precondition to develop the disease, genetic factors account for about 50-60% of the risk of developing alcoholism. These observations have stimulated the use of selected strains and lines of rodents as models to investigate genetically determined differences in behavioral and neurochemical traits related to addictive disorders. Among those, the Roman high (RHA)- and low (RLA)-avoidance rats are selectively bred for rapid vs poor acquisition of active avoidance, respectively, and differ markedly in emotional reactivity, coping style, and behavioral and neurochemical responses to a number of drugs of abuse such as morphine, ethanol and psychostimulants. On the other hand, one of the most efficacious approaches to model several aspects of alcoholism is represented by the use of rat lines selectively bred for high ethanol preference or excessive ethanol drinking that represent well-suited experimental models to investigate the biological bases of alcoholism by virtue of their predictive, face, and construct validity. In particular, Sardinian alcohol-preferring (sP) rats constitute one of these rat lines selectively bred for excessive ethanol intake. Thus, when given a choice between 10% (v/v) ethanol and water, under the standard, home cage 2-bottle regimen, with unlimited access for 24 h/day, sP rats display a clear preference for the ethanol solution and daily consume 6 to 7 g/kg of pure ethanol. Among the kinases and transcription factors that have been deeply investigated in the recent years for their involvement in the molecular basis of addiction, the extracellular signalregulated kinase (ERK) occupies a strategic position, both at the cytoplasmic and nuclear level. In fact, activation of ERK is critical …
abstract: Clinical studies indicate that genetically determined personality traits, such as sensation seeking and impulsivity, are associated with increased drug addiction liability. Thus, in spite of the fact that for instance a prolonged ethanol exposure is an essential precondition to develop the disease, genetic factors account for about 50-60% of the risk of developing alcoholism. These observations have stimulated the use of selected strains and lines of rodents as models to investigate genetically determined differences in behavioral and neurochemical traits related to addictive disorders. Among those, the Roman high (RHA)- and low (RLA)-avoidance rats are selectively bred for rapid vs poor acquisition of active avoidance, respectively, and differ markedly in emotional reactivity, coping style, and behavioral and neurochemical responses to a number of drugs of abuse such as morphine, ethanol and psychostimulants. On the other hand, one of the most efficacious approaches to model several aspects of alcoholism is represented by the use of rat lines selectively bred for high ethanol preference or excessive ethanol drinking that represent well-suited experimental models to investigate the biological bases of alcoholism by virtue of their predictive, face, and construct validity. In particular, Sardinian alcohol-preferring (sP) rats constitute one of these rat lines selectively bred for excessive ethanol intake. Thus, when given a choice between 10% (v/v) ethanol and water, under the standard, home cage 2-bottle regimen, with unlimited access for 24 h/day, sP rats display a clear preference for the ethanol solution and daily consume 6 to 7 g/kg of pure ethanol. Among the kinases and transcription factors that have been deeply investigated in the recent years for their involvement in the molecular basis of addiction, the extracellular signalregulated kinase (ERK) occupies a strategic position, both at the cytoplasmic and nuclear level. In fact, activation of ERK is critical …
author: ROSAS, MICHELA
language: ita
keywords: addiction, cocaina, cociane, dipendenza, etanolo, ethanol, morfina, morphine, nucleus accumbens, pERK, psychogenetic selction, selezione genetica, Settore BIO/14 - Farmacologia
date published: 2015-05-06
date modified: 2026-07-24T01:30:07Z
provider: Università di Cagliari
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Cagliari

PropertyValue
property ID: Handle
value: http://hdl.handle.net/11584/266619