La Metabolomica: una nuova era in Cardiologia. Le nostre esperienze originali nei campi dell' insufficienza cardiaca, della cardiopatia ischemica e dell' ipertensione polmonare
type: CreativeWork
description: Purpose. Metabolomics (MBS) is a “omics” science that enables the assessment of a broad range of metabolites providing a metabolic picture able to identify metabolic changes. On these basis we carried out a metabolomics on three settings of cardiovascular diseases: a) heart failure; b) Stable coronary artery disease; c) Pulmonary hypertension in systemic sclerosis. Heart Failure Heart failure (HF) is characterized by a series of maladaptive metabolic changes, which have recently been proposed as a new therapeutic target. A proton nuclear magnetic resonance (1H NMR)-based MBS analysis was performed on blood samples of 3 groups of individuals: nine control individuals (Group A); nine HF patients with mildmoderate impairment of left ventricle ejection fraction (LVEF 35-50%; Group B); fifteen HF patients with severe LVEF impairment (EF <35%; Group C). Specimens were analyzed with a 1HNMR 500MHz spectrometer. A supervised PLS-DA Projection on Latent Structures Discriminant Analysis was applied to realize a descriptive model of HF. Morevoer, we carried out an echocardiographic evaluation of whole study population, including an assessment of Longitudinal Strain (S) and Strain Rate (SR) values using Speakle Tracking Imaging. The three groups showed a progressive impairment of systolic function from Group A to Group C, with intermediate values in Group B. The application of Pattern-recognition methods to 1H-NMR spectra identified 3 metabolic clusters related to A, B and C groups, respectively. The discrimination were related to a metabolic fingerprint depending on a limited set of metabolites. Our preliminary data show that MBS is a sensitive method, which can be effectively used in association with traditional techniques for the evaluation of HF. This new tool may permit to investigate the perturbed metabolic pathways in HF and their correlation with impaired myocardial function and could lead to the identification of innovative therapeutic approaches. Stable coronary arter…
abstract: Purpose. Metabolomics (MBS) is a “omics” science that enables the assessment of a broad range of metabolites providing a metabolic picture able to identify metabolic changes. On these basis we carried out a metabolomics on three settings of cardiovascular diseases: a) heart failure; b) Stable coronary artery disease; c) Pulmonary hypertension in systemic sclerosis. Heart Failure Heart failure (HF) is characterized by a series of maladaptive metabolic changes, which have recently been proposed as a new therapeutic target. A proton nuclear magnetic resonance (1H NMR)-based MBS analysis was performed on blood samples of 3 groups of individuals: nine control individuals (Group A); nine HF patients with mildmoderate impairment of left ventricle ejection fraction (LVEF 35-50%; Group B); fifteen HF patients with severe LVEF impairment (EF <35%; Group C). Specimens were analyzed with a 1HNMR 500MHz spectrometer. A supervised PLS-DA Projection on Latent Structures Discriminant Analysis was applied to realize a descriptive model of HF. Morevoer, we carried out an echocardiographic evaluation of whole study population, including an assessment of Longitudinal Strain (S) and Strain Rate (SR) values using Speakle Tracking Imaging. The three groups showed a progressive impairment of systolic function from Group A to Group C, with intermediate values in Group B. The application of Pattern-recognition methods to 1H-NMR spectra identified 3 metabolic clusters related to A, B and C groups, respectively. The discrimination were related to a metabolic fingerprint depending on a limited set of metabolites. Our preliminary data show that MBS is a sensitive method, which can be effectively used in association with traditional techniques for the evaluation of HF. This new tool may permit to investigate the perturbed metabolic pathways in HF and their correlation with impaired myocardial function and could lead to the identification of innovative therapeutic approaches. Stable coronary arter…
author: DEIDDA, MARTINO
language: ita
keywords: cardiopatia ischemica, coronary artery disease, heart failure, ipertensione polmonare, metabolomica, metabolomics, pulmonary hypertension, scompenso cardiaco, Settore MED/11 - Malattie dell'Apparato Cardiovascolare
date published: 2015-04-15
date modified: 2026-07-24T01:30:07Z
provider: Università di Cagliari
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Cagliari

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property ID: Handle
value: http://hdl.handle.net/11584/266580