{"id":{"repo_id":"cagliari","oai_identifier":"oai:iris.unica.it:11584/265998"},"canonical_url":"https://search.dev.ndltd.org/etd/cagliari/oai:iris.unica.it:11584/265998","repository":{"repo_id":"cagliari","name":"Università di Cagliari","base_url":"https://iris.unica.it/oai/request"},"display":{"title":"Indagine etnofarmacologica su Casimiroa edulis Llave et Lex","abstract":"In order to evaluate the effects produced by the extracts of leaves, seeds and bark from Casimiroa edulis cultivated in Sardinia on the central nervous system, different behavioral tests were performed: spontaneous motor activity, anxyolitic, antidepressant, hypnotic-sedative, anticataleptic, anticonvulsant, antinociceptive and antinflammatory activities. The results revealed that the extract of seeds reduced spontaneous motor activity and rearing; in the forced swimming test (FST) it caused a potent sedative effect; in the test of carrageenan-induced paw edema it showed an antinflammatory activity; furthermore it reduced writhing acetic acid-induced (antinociceptive activity) and convulsion lithium-pilocarpine induced, while it significantly prolonged pentobarbital-induced hypnosis. The extract of leaves produced a like-anxyolitic action in the elevated plus maze test; in the FST it was as effective as fluoxetine in inducing shortening of immobility (like-antidepressant action); it reduced catalepsy haloperidol and PTZ-induced. The extract of bark significantly reduced immobility time in the FST and it increased pentobarbital-induced hypnosis.","abstract_html":"In order to evaluate the effects produced by the extracts of leaves, seeds and bark from Casimiroa edulis cultivated in Sardinia on the central nervous system, different behavioral tests were performed: spontaneous motor activity, anxyolitic, antidepressant, hypnotic-sedative, anticataleptic, anticonvulsant, antinociceptive and antinflammatory activities. The results revealed that the extract of seeds reduced spontaneous motor activity and rearing; in the forced swimming test (FST) it caused a potent sedative effect; in the test of carrageenan-induced paw edema it showed an antinflammatory activity; furthermore it reduced writhing acetic acid-induced (antinociceptive activity) and convulsion lithium-pilocarpine induced, while it significantly prolonged pentobarbital-induced hypnosis. The extract of leaves produced a like-anxyolitic action in the elevated plus maze test; in the FST it was as effective as fluoxetine in inducing shortening of immobility (like-antidepressant action); it reduced catalepsy haloperidol and PTZ-induced. The extract of bark significantly reduced immobility time in the FST and it increased pentobarbital-induced hypnosis.","abstract_has_math":false,"creators":["SANNA, CINZIA"],"institution":"Università degli Studi di Cagliari","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008-12-18","date_published":"2008-12-18","updated_at":"2026-07-24T01:30:12Z","subjects":["Casimiroa edulis","anticonvulsant","antidepressant","anxyolitic","sedative","Settore BIO/15 - Biologia Farmaceutica"],"languages":["ita"],"rights":["info:eu-repo/semantics/openAccess","license:Non specificato"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11584/265998","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["SANNA, CINZIA"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2008-12-18"]},{"key":"dc:publisher","label":"Institution","values":["Università degli Studi di Cagliari"]},{"key":"dc:relation","label":"Dc Relation","values":["numberofpages:90"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Casimiroa edulis","anticonvulsant","antidepressant","anxyolitic","sedative","Settore BIO/15 - Biologia Farmaceutica"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ita"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess","license:Non specificato"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/11584/265998"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["In order to evaluate the effects produced by the extracts of leaves, seeds and bark from Casimiroa edulis cultivated in Sardinia on the central nervous system, different behavioral tests were performed: spontaneous motor activity, anxyolitic, antidepressant, hypnotic-sedative, anticataleptic, anticonvulsant, antinociceptive and antinflammatory activities. The results revealed that the extract of seeds reduced spontaneous motor activity and rearing; in the forced swimming test (FST) it caused a potent sedative effect; in the test of carrageenan-induced paw edema it showed an antinflammatory activity; furthermore it reduced writhing acetic acid-induced (antinociceptive activity) and convulsion lithium-pilocarpine induced, while it significantly prolonged pentobarbital-induced hypnosis. The extract of leaves produced a like-anxyolitic action in the elevated plus maze test; in the FST it was as effective as fluoxetine in inducing shortening of immobility (like-antidepressant action); it reduced catalepsy haloperidol and PTZ-induced. The extract of bark significantly reduced immobility time in the FST and it increased pentobarbital-induced hypnosis."]},{"key":"dc:title","label":"Title","values":["Indagine etnofarmacologica su Casimiroa edulis Llave et Lex"]}]}],"canonical_facts":{"dc:creator":["SANNA, CINZIA"],"dc:date":["2008-12-18"],"dc:description":["In order to evaluate the effects produced by the extracts of leaves, seeds and bark from Casimiroa edulis cultivated in Sardinia on the central nervous system, different behavioral tests were performed: spontaneous motor activity, anxyolitic, antidepressant, hypnotic-sedative, anticataleptic, anticonvulsant, antinociceptive and antinflammatory activities. The results revealed that the extract of seeds reduced spontaneous motor activity and rearing; in the forced swimming test (FST) it caused a potent sedative effect; in the test of carrageenan-induced paw edema it showed an antinflammatory activity; furthermore it reduced writhing acetic acid-induced (antinociceptive activity) and convulsion lithium-pilocarpine induced, while it significantly prolonged pentobarbital-induced hypnosis. The extract of leaves produced a like-anxyolitic action in the elevated plus maze test; in the FST it was as effective as fluoxetine in inducing shortening of immobility (like-antidepressant action); it reduced catalepsy haloperidol and PTZ-induced. The extract of bark significantly reduced immobility time in the FST and it increased pentobarbital-induced hypnosis."],"dc:identifier":["http://hdl.handle.net/11584/265998"],"dc:language":["ita"],"dc:publisher":["Università degli Studi di Cagliari"],"dc:relation":["numberofpages:90"],"dc:rights":["info:eu-repo/semantics/openAccess","license:Non specificato"],"dc:subject":["Casimiroa edulis","anticonvulsant","antidepressant","anxyolitic","sedative","Settore BIO/15 - Biologia Farmaceutica"],"dc:title":["Indagine etnofarmacologica su Casimiroa edulis Llave et Lex"],"dc:type":["info:eu-repo/semantics/doctoralThesis"]},"updated_at":"2026-07-24T01:30:12Z"}