Characterizing neurodegeneration, neuroinflammation and immunological status through multimodal strategies in type 1 diabetes mellitus and relapsing-remitting multiple sclerosis
type: CreativeWork
description: Type 1 diabetes mellitus (T1DM) and Multiple sclerosis (MS) are chronic organ-specific diseases caused by immune system dysfunction. The study of T1DM and MS has gained increasing attention because of their high prevalence, progressive nature, impact on patients' daily lives, the lifelong management these conditions require, and the increased co-occurrence of both pathologies. Nevertheless, despite advances in the availability of therapeutic options, the mechanisms driving their progression are still not fully understood. In fact, both autoimmune illnesses have more aetiologic and pathologic similarities than one might anticipate, including systemic dysregulations, central nervous system (CNS)-specific components of neuroinflammation and axonal damage, or the presence of cognitive impairment, among others. Moreover, although both conditions manifest immune-mediated tissue destruction, the precise inflammatory-immune profiles and regulatory mechanisms underlying these processes remain unexplored. Thus, while MS is recognized primarily for its neuroinflammatory effects and its neurodegeneration markers are relatively well characterized by neuroimaging and biochemical approaches, increasing evidence suggests that T1DM may also be associated with CNS alterations in addition to peripheral neuropathy, so deeper investigations into CNS involvement are still needed. This knowledge could be crucial for identifying biomarkers, assessing cognitive impairment, and improving early detection and therapeutic strategies for neurological and associated complications in those diseases. Given the importance of conducting a comprehensive comparative analysis, this thesis is structured into three distinct but interconnected studies to ensure clarity and an in-depth investigation of T1DM and MS. Each study focuses on a key aspect of disease pathophysiology, neurodegeneration, systemic inflammation and immunity, and molecular mechanisms, as detailed in the following sections. The first st…
abstract: Type 1 diabetes mellitus (T1DM) and Multiple sclerosis (MS) are chronic organ-specific diseases caused by immune system dysfunction. The study of T1DM and MS has gained increasing attention because of their high prevalence, progressive nature, impact on patients' daily lives, the lifelong management these conditions require, and the increased co-occurrence of both pathologies. Nevertheless, despite advances in the availability of therapeutic options, the mechanisms driving their progression are still not fully understood. In fact, both autoimmune illnesses have more aetiologic and pathologic similarities than one might anticipate, including systemic dysregulations, central nervous system (CNS)-specific components of neuroinflammation and axonal damage, or the presence of cognitive impairment, among others. Moreover, although both conditions manifest immune-mediated tissue destruction, the precise inflammatory-immune profiles and regulatory mechanisms underlying these processes remain unexplored. Thus, while MS is recognized primarily for its neuroinflammatory effects and its neurodegeneration markers are relatively well characterized by neuroimaging and biochemical approaches, increasing evidence suggests that T1DM may also be associated with CNS alterations in addition to peripheral neuropathy, so deeper investigations into CNS involvement are still needed. This knowledge could be crucial for identifying biomarkers, assessing cognitive impairment, and improving early detection and therapeutic strategies for neurological and associated complications in those diseases. Given the importance of conducting a comprehensive comparative analysis, this thesis is structured into three distinct but interconnected studies to ensure clarity and an in-depth investigation of T1DM and MS. Each study focuses on a key aspect of disease pathophysiology, neurodegeneration, systemic inflammation and immunity, and molecular mechanisms, as detailed in the following sections. The first st…
author: Cano Cano, Fátima
language: eng
license: http://creativecommons.org/licenses/by-nc-nd/4.0/
date published: 2025-06-13
date modified: 2026-07-24T01:29:47Z
provider: Universidad de Cadiz
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Universidad de Cadiz

PropertyValue
property ID: Handle
value: http://hdl.handle.net/10498/38117