{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/86841"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/86841","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Time-of-Flight Secondary Ion Mass Spectrometry Studies of Interfaces of Biomaterials, Cells, and Metal Alloy Powders","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Sen, Shohini; 0000-0002-4369-0967"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Gardella, Joseph","Chemistry"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-02-25T23:23:19Z","date_published":"2025-02-25T23:23:19Z","updated_at":"2026-07-27T19:05:37Z","subjects":["analytical chemistry","polymer chemistry","materials science"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/86841","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gardella, Joseph","Chemistry"]},{"key":"dc:creator","label":"Author","values":["Sen, Shohini; 0000-0002-4369-0967"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-02-25T23:23:19Z","2020","2020-08-05 14:30:48"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["analytical chemistry","polymer chemistry","materials science"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/86841"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","This dissertation is focused on understanding how the chemistry of surfaces of different materials such as biomaterials, metal alloy powders, and cells influences their function and behavior. The bulk behavior of materials can be studied with various different forms of instrumentation. However, the surface behavior must be studied with surface-sensitive spectroscopies and spectro-microscopies. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a surface-sensitive spectro-microscopic technique that allows for the understanding and imaging of the chemistry of the first several nanometers of a surface. This tells us about the behavior of the first several atomic layers of a surface. This powerful technique has allowed us to understand how surface chemistry of biomaterials can influence the behavior of surface-bound growth factors for delivery to wounds that are 3-5 nanometers in size. It has also permitted analysis of the first 1-2 nanometers of metal alloy powders and study monolayers of water and oxygen adsorbed at the surface. Finally, it has enabled us to image and differentiate the lipid distributions within human colon cancer cells. Other surface sensitive spectroscopies have also been featured in this dissertation. However, the primary body of the dissertation is a display of the amazing abilities of ToF-SIMS to tell us about multiple different surfaces of great interest in tissue regeneration, energy and the military, and the interior of cells.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Time-of-Flight Secondary Ion Mass Spectrometry Studies of Interfaces of Biomaterials, Cells, and Metal Alloy Powders"]}]}],"canonical_facts":{"dc:contributor":["Gardella, Joseph","Chemistry"],"dc:creator":["Sen, Shohini; 0000-0002-4369-0967"],"dc:date":["2025-02-25T23:23:19Z","2020","2020-08-05 14:30:48"],"dc:description":["Ph.D.","This dissertation is focused on understanding how the chemistry of surfaces of different materials such as biomaterials, metal alloy powders, and cells influences their function and behavior. The bulk behavior of materials can be studied with various different forms of instrumentation. However, the surface behavior must be studied with surface-sensitive spectroscopies and spectro-microscopies. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a surface-sensitive spectro-microscopic technique that allows for the understanding and imaging of the chemistry of the first several nanometers of a surface. This tells us about the behavior of the first several atomic layers of a surface. This powerful technique has allowed us to understand how surface chemistry of biomaterials can influence the behavior of surface-bound growth factors for delivery to wounds that are 3-5 nanometers in size. It has also permitted analysis of the first 1-2 nanometers of metal alloy powders and study monolayers of water and oxygen adsorbed at the surface. Finally, it has enabled us to image and differentiate the lipid distributions within human colon cancer cells. Other surface sensitive spectroscopies have also been featured in this dissertation. However, the primary body of the dissertation is a display of the amazing abilities of ToF-SIMS to tell us about multiple different surfaces of great interest in tissue regeneration, energy and the military, and the interior of cells.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/86841"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["analytical chemistry","polymer chemistry","materials science"],"dc:title":["Time-of-Flight Secondary Ion Mass Spectrometry Studies of Interfaces of Biomaterials, Cells, and Metal Alloy Powders"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:37Z"}