{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/86832"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/86832","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Under-Consumption of Water by Thirsty Sucrose-Maintained Rats","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Volcko, Karin"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Daniels, Derek","Psychology"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-02-25T23:23:14Z","date_published":"2025-02-25T23:23:14Z","updated_at":"2026-07-27T19:05:37Z","subjects":["behavioral psychology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/86832","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Daniels, Derek","Psychology"]},{"key":"dc:creator","label":"Author","values":["Volcko, Karin"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-02-25T23:23:14Z","2020","2020-08-03 10:14:40"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["behavioral psychology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/86832"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Rats that have never had anything but a 5% sucrose solution to drink from weaning until testing in adulthood under-consume water relative to water-maintained controls when challenged with subcutaneous hypertonic saline (HS). This project was designed to clarify if this is because the fluid that is consumed early in life determines adult drinking behavior, or because the fluid that is consumed most recently changes the drinking response. Furthermore, we tested whether or not sucrose consumption needs to be exclusive, and whether the changes in consumption affect hydration. To this end, we manipulated which fluid (water or sucrose) was available and evaluated the effect of changing the available fluid 1 or 7 weeks after weaning, or providing 1-hr daily access to sucrose while otherwise only having water available. In adulthood, rats were tested in three ways: 1) given either water or sucrose to drink after HS injection, 2) given water or sucrose after overnight fluid deprivation, and 3) given both fluids to drink simultaneously after HS injection. Some groups underwent all three tests, and others only the first test. Finally, plasma osmolality was measured after HS injection. We found that sucrose need not be exclusive to see under-consumption of water, but 1-hr daily access is not sufficient to cause differences in intake. The amount of water that rats drank was determined by the fluid the rats had the week before testing. Perturbations in burst number and size, likely indicative of changes in postingestive and orosensory feedback, were often present despite normalized intake after one week of drinking water. Rats that under-consumed water after HS challenge failed to bring plasma osmolality back to baseline two hours after injection. Together, these data demonstrate that drinking water is subject to negative contrast effects in thirsty rats accustomed to drinking sucrose, and that this negatively impacts their hydration.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Under-Consumption of Water by Thirsty Sucrose-Maintained Rats"]}]}],"canonical_facts":{"dc:contributor":["Daniels, Derek","Psychology"],"dc:creator":["Volcko, Karin"],"dc:date":["2025-02-25T23:23:14Z","2020","2020-08-03 10:14:40"],"dc:description":["Ph.D.","Rats that have never had anything but a 5% sucrose solution to drink from weaning until testing in adulthood under-consume water relative to water-maintained controls when challenged with subcutaneous hypertonic saline (HS). This project was designed to clarify if this is because the fluid that is consumed early in life determines adult drinking behavior, or because the fluid that is consumed most recently changes the drinking response. Furthermore, we tested whether or not sucrose consumption needs to be exclusive, and whether the changes in consumption affect hydration. To this end, we manipulated which fluid (water or sucrose) was available and evaluated the effect of changing the available fluid 1 or 7 weeks after weaning, or providing 1-hr daily access to sucrose while otherwise only having water available. In adulthood, rats were tested in three ways: 1) given either water or sucrose to drink after HS injection, 2) given water or sucrose after overnight fluid deprivation, and 3) given both fluids to drink simultaneously after HS injection. Some groups underwent all three tests, and others only the first test. Finally, plasma osmolality was measured after HS injection. We found that sucrose need not be exclusive to see under-consumption of water, but 1-hr daily access is not sufficient to cause differences in intake. The amount of water that rats drank was determined by the fluid the rats had the week before testing. Perturbations in burst number and size, likely indicative of changes in postingestive and orosensory feedback, were often present despite normalized intake after one week of drinking water. Rats that under-consumed water after HS challenge failed to bring plasma osmolality back to baseline two hours after injection. Together, these data demonstrate that drinking water is subject to negative contrast effects in thirsty rats accustomed to drinking sucrose, and that this negatively impacts their hydration.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/86832"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["behavioral psychology"],"dc:title":["Under-Consumption of Water by Thirsty Sucrose-Maintained Rats"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:37Z"}