{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/86769"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/86769","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Identification of Novel Prognostic Biomarkers in Epithelial Ovarian Cancer","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Stenzel, Ashley"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Moysich, Kirsten","Roswell Park"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-02-21T21:44:54Z","date_published":"2025-02-21T21:44:54Z","updated_at":"2026-07-27T19:05:37Z","subjects":["epidemiology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/86769","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Moysich, Kirsten","Roswell Park"]},{"key":"dc:creator","label":"Author","values":["Stenzel, Ashley"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-02-21T21:44:54Z","2020"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["epidemiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/86769"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","The research in this dissertation demonstrates that, in a larger study adjusting for clinical covariates, circulating, immunophenotypically defined M-MDSCs may be an independent prognostic biomarker for EOC. Identifying this association in the peripheral blood of EOC patients offers a non-invasive biomarker that is more applicable to a broader patient population. As such, future research should be conducted to understand the value of clinical utilization of M-MDSCs in predicting patient outcomes and treatment planning for EOC. Existing literature in murine models has demonstrated the potential to reduce MDSCs through pharmacological interventions as well as lifestyle interventions such as physical activity interventions, suggesting that intervening with exercise therapy may improve immune profiles. Continuing to explore the relationships between MDSCs in EOC survival, as well as other lifestyle characteristics in humans that may influence MDSC populations in EOC may demonstrate ideal interventions to target this cell population to improve survival. Additionally, the research performed in this dissertation provides a starting point for examining IRF8 expression in EOC prognosis. Our results demonstrate no association between protein expression of IRF8 and EOC mortality, but reduced risk of dying among EOC patients with high mRNA expression of IRF8. Additional studies on IRF8 in EOC prognosis are necessary to identify the ideal methods for measuring IRF8 expression in this malignancy, as well as further confirming any potential prognostic value. IRF8 is a particularly interesting target for potential intervention given existing studies in model systems with low myeloid IRF8 expression, treated with targeted therapy such as interferon-γ that suggest IRF8 expression can be increased through such therapies, which can subsequently reduce MDSC populations upon re-expression. Future studies examining methodology for measuring IRF8 will allow the field to move forward with this potential biomarker in future research and clinical care for EOC.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Identification of Novel Prognostic Biomarkers in Epithelial Ovarian Cancer"]}]}],"canonical_facts":{"dc:contributor":["Moysich, Kirsten","Roswell Park"],"dc:creator":["Stenzel, Ashley"],"dc:date":["2025-02-21T21:44:54Z","2020"],"dc:description":["Ph.D.","The research in this dissertation demonstrates that, in a larger study adjusting for clinical covariates, circulating, immunophenotypically defined M-MDSCs may be an independent prognostic biomarker for EOC. Identifying this association in the peripheral blood of EOC patients offers a non-invasive biomarker that is more applicable to a broader patient population. As such, future research should be conducted to understand the value of clinical utilization of M-MDSCs in predicting patient outcomes and treatment planning for EOC. Existing literature in murine models has demonstrated the potential to reduce MDSCs through pharmacological interventions as well as lifestyle interventions such as physical activity interventions, suggesting that intervening with exercise therapy may improve immune profiles. Continuing to explore the relationships between MDSCs in EOC survival, as well as other lifestyle characteristics in humans that may influence MDSC populations in EOC may demonstrate ideal interventions to target this cell population to improve survival. Additionally, the research performed in this dissertation provides a starting point for examining IRF8 expression in EOC prognosis. Our results demonstrate no association between protein expression of IRF8 and EOC mortality, but reduced risk of dying among EOC patients with high mRNA expression of IRF8. Additional studies on IRF8 in EOC prognosis are necessary to identify the ideal methods for measuring IRF8 expression in this malignancy, as well as further confirming any potential prognostic value. IRF8 is a particularly interesting target for potential intervention given existing studies in model systems with low myeloid IRF8 expression, treated with targeted therapy such as interferon-γ that suggest IRF8 expression can be increased through such therapies, which can subsequently reduce MDSC populations upon re-expression. Future studies examining methodology for measuring IRF8 will allow the field to move forward with this potential biomarker in future research and clinical care for EOC.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/86769"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["epidemiology"],"dc:title":["Identification of Novel Prognostic Biomarkers in Epithelial Ovarian Cancer"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:37Z"}