{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/86658"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/86658","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Development of Photoacoustic Technologies for Breast Cancer Imaging","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Nyayapathi, Nikhila; 0000-0002-3711-797X"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Oh, Kwang","Electrical Engineering"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-02-21T21:36:10Z","date_published":"2025-02-21T21:36:10Z","updated_at":"2026-07-27T19:05:34Z","subjects":["electrical engineering","biomedical engineering","optics"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/86658","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Oh, Kwang","Electrical Engineering"]},{"key":"dc:creator","label":"Author","values":["Nyayapathi, Nikhila; 0000-0002-3711-797X"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-02-21T21:36:10Z","2020"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["electrical engineering","biomedical engineering","optics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/86658"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Breast cancer is the second leading cause of cancer-related deaths. In order to improve survival rates, early detection is very important. However, current imaging techniques that are commonly used for breast cancer screening have certain limitations. For instance, women with dense breasts are at a higher risk for breast cancer, however, mammograms have decreased sensitivity to dense breast tissue. Also, with the exposure to ionizing radiation and compression of breasts between metal plates, this procedure causes a lot of discomfort to the patient. While ultrasound is patient-friendly and has better sensitivity than a mammogram for dense breasts, it is prone to false positives and is heavily operator dependent. Magnetic resonance imaging (MRI) has good sensitivity and specificity for dense breasts. However, it is an expensive procedure and also requires an injection of Gadolinium as a contrast agent. In certain cases, this can lead to an allergic reaction, renal failure, or deposition in the central nervous system. To overcome the limitations mentioned above and to improve sensitivity for patients with dense breasts, we have built an imaging system based on photoacoustics. This system combines optical contrasts with acoustic detection, and thus obtains a snapshot of the angiographic features in human breast. Using near infrared light (NIR) for excitation, hemoglobin as endogenous contrast, and dual transducer geometry, we are able to visualize through 7 cm of breast tissue, a first in this field. Our system offers high spatial resolution, fast imaging capability, and convenient correlation with all existing imaging modalities along with better sensitivity towards dense breast tissue. There are five chapters in this dissertation. First, Chapter 1 introduces the concept of photoacoustics briefly and gives a comprehensive overview of existing PA-based breast imaging systems. Next, Chapter 2 describes the development of our Dual Scan Mammoscope and its imaging results. Then, Chapter 3 gives an overview of our clinical testing at Windsong Radiology and Roswell Park Comprehensive Cancer Center and summarizes the results obtained from breast cancer patients. After that, Chapter 4 describes deep-tissue photoacoustic imaging with contrast agents. Finally, Chapter 5 presents the conclusion and future direction for this work.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Development of Photoacoustic Technologies for Breast Cancer Imaging"]}]}],"canonical_facts":{"dc:contributor":["Oh, Kwang","Electrical Engineering"],"dc:creator":["Nyayapathi, Nikhila; 0000-0002-3711-797X"],"dc:date":["2025-02-21T21:36:10Z","2020"],"dc:description":["Ph.D.","Breast cancer is the second leading cause of cancer-related deaths. In order to improve survival rates, early detection is very important. However, current imaging techniques that are commonly used for breast cancer screening have certain limitations. For instance, women with dense breasts are at a higher risk for breast cancer, however, mammograms have decreased sensitivity to dense breast tissue. Also, with the exposure to ionizing radiation and compression of breasts between metal plates, this procedure causes a lot of discomfort to the patient. While ultrasound is patient-friendly and has better sensitivity than a mammogram for dense breasts, it is prone to false positives and is heavily operator dependent. Magnetic resonance imaging (MRI) has good sensitivity and specificity for dense breasts. However, it is an expensive procedure and also requires an injection of Gadolinium as a contrast agent. In certain cases, this can lead to an allergic reaction, renal failure, or deposition in the central nervous system. To overcome the limitations mentioned above and to improve sensitivity for patients with dense breasts, we have built an imaging system based on photoacoustics. This system combines optical contrasts with acoustic detection, and thus obtains a snapshot of the angiographic features in human breast. Using near infrared light (NIR) for excitation, hemoglobin as endogenous contrast, and dual transducer geometry, we are able to visualize through 7 cm of breast tissue, a first in this field. Our system offers high spatial resolution, fast imaging capability, and convenient correlation with all existing imaging modalities along with better sensitivity towards dense breast tissue. There are five chapters in this dissertation. First, Chapter 1 introduces the concept of photoacoustics briefly and gives a comprehensive overview of existing PA-based breast imaging systems. Next, Chapter 2 describes the development of our Dual Scan Mammoscope and its imaging results. Then, Chapter 3 gives an overview of our clinical testing at Windsong Radiology and Roswell Park Comprehensive Cancer Center and summarizes the results obtained from breast cancer patients. After that, Chapter 4 describes deep-tissue photoacoustic imaging with contrast agents. Finally, Chapter 5 presents the conclusion and future direction for this work.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/86658"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["electrical engineering","biomedical engineering","optics"],"dc:title":["Development of Photoacoustic Technologies for Breast Cancer Imaging"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:34Z"}