{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/86638"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/86638","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"CD28 Promotes Mitochondrial Metabolism to Support Myeloma Cell Survival","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Rogemoser, Phuong"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Lee, Kelvin","Roswell Park"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-02-21T21:35:54Z","date_published":"2025-02-21T21:35:54Z","updated_at":"2026-07-27T19:05:32Z","subjects":["oncology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/86638","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Lee, Kelvin","Roswell Park"]},{"key":"dc:creator","label":"Author","values":["Rogemoser, Phuong"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-02-21T21:35:54Z","2020"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["oncology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/86638"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","Multiple myeloma (MM) is a malignancy of bone marrow plasma cells (BMPCs). Despite advances in treatments, MM remains incurable due to the development of therapy resistant cells. The bone marrow (BM) microenvironment not only produces important soluble pro-MM survival factors, but also directly interacts with MM cells via cell-cell contact to upregulate pro-tumorigenesis pathways to support MM survival and therapy resistance. We previously described the critical role of CD28-CD80/CD86 interaction between MM cells and bone marrow dendritic cells. Despite the well-recognized central involvement of CD28 in supporting MM survival, the intrinsic molecular functions of CD28 remain to be delineated. In this study, we reveal preliminary data underlying CD28's function in promoting mitochondrial respiration capacity through the upregulation of the mitochondria biogenesis master regulator PGC1-β. We further defined fatty acids as essential fuels for CD28-mediated mitochondrial metabolism and that inhibition of fatty acid oxidation diminishes CD28's pro-survival effect in vitro. Taken together, our study suggests PGC1-β is a novel downstream signal mediating CD28's pro-metabolic functions and that inhibition of fatty acid metabolism could be applied in anti-MM treatment.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["CD28 Promotes Mitochondrial Metabolism to Support Myeloma Cell Survival"]}]}],"canonical_facts":{"dc:contributor":["Lee, Kelvin","Roswell Park"],"dc:creator":["Rogemoser, Phuong"],"dc:date":["2025-02-21T21:35:54Z","2020"],"dc:description":["M.S.","Multiple myeloma (MM) is a malignancy of bone marrow plasma cells (BMPCs). Despite advances in treatments, MM remains incurable due to the development of therapy resistant cells. The bone marrow (BM) microenvironment not only produces important soluble pro-MM survival factors, but also directly interacts with MM cells via cell-cell contact to upregulate pro-tumorigenesis pathways to support MM survival and therapy resistance. We previously described the critical role of CD28-CD80/CD86 interaction between MM cells and bone marrow dendritic cells. Despite the well-recognized central involvement of CD28 in supporting MM survival, the intrinsic molecular functions of CD28 remain to be delineated. In this study, we reveal preliminary data underlying CD28's function in promoting mitochondrial respiration capacity through the upregulation of the mitochondria biogenesis master regulator PGC1-β. We further defined fatty acids as essential fuels for CD28-mediated mitochondrial metabolism and that inhibition of fatty acid oxidation diminishes CD28's pro-survival effect in vitro. Taken together, our study suggests PGC1-β is a novel downstream signal mediating CD28's pro-metabolic functions and that inhibition of fatty acid metabolism could be applied in anti-MM treatment.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/86638"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["oncology"],"dc:title":["CD28 Promotes Mitochondrial Metabolism to Support Myeloma Cell Survival"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:32Z"}