{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/86461"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/86461","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Auditory Function in CBA/CaJ Mice Following Blast-Induced Traumatic Brain Injury (TBI)","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Burke, Kali; 0000-0002-1736-480X"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Dent, Micheal","Psychology"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-02-21T17:22:40Z","date_published":"2025-02-21T17:22:40Z","updated_at":"2026-07-27T19:05:32Z","subjects":["cognitive psychology","behavioral psychology","audiology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/86461","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Dent, Micheal","Psychology"]},{"key":"dc:creator","label":"Author","values":["Burke, Kali; 0000-0002-1736-480X"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-02-21T17:22:40Z","2020"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["cognitive psychology","behavioral psychology","audiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/86461"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","In this dissertation, I investigated how blast-induced traumatic brain injury (TBI) affected auditory function in mice. In experiment 1, I determined the effects of TBI on the physiological responses of the auditory brainstem, outer hair cells, and cochlea when presented with simple acoustic stimuli. In experiment 2, I used behavioral methods to evaluate differences in perception of simple and complex acoustic stimuli before and after TBI. Through these experiments, we found that the auditory system of laboratory mice is susceptible to blast exposures. In the physiological experiment, the magnitude of the response in the ear was reduced and the time it took for this response to peak increased in blasted subjects relative to uninjured controls after the blast. The high frequency sensitivity of mice was extremely elevated after blast exposures in most subjects, resulting in a reduced range of audibility. Interestingly, in the behavioral experiment, many mice were still able to detect a pure tone of the frequency that had elicited no physiological response in experiment 1. Mice could also detect ultrasonic vocalizations and tones spanning their normal hearing range after blast exposures, albeit to a lesser degree than prior to the exposures. These results have implications for the ways in which human hearing is affected following a similar exposure, because audiometry in the clinic often mirrors the behavioral and physiological measurements tested here. The variability in behavioral responses between blasted mice is significant, suggesting that clinical measurements at acute time points may not accurately reflect the hearing abilities of each individual. These experiments are unique because of the comparisons between physiology and behavior, but are also the first studies to examine changes over three months following injury acquisition for individuals exposed to a blast.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Auditory Function in CBA/CaJ Mice Following Blast-Induced Traumatic Brain Injury (TBI)"]}]}],"canonical_facts":{"dc:contributor":["Dent, Micheal","Psychology"],"dc:creator":["Burke, Kali; 0000-0002-1736-480X"],"dc:date":["2025-02-21T17:22:40Z","2020"],"dc:description":["Ph.D.","In this dissertation, I investigated how blast-induced traumatic brain injury (TBI) affected auditory function in mice. In experiment 1, I determined the effects of TBI on the physiological responses of the auditory brainstem, outer hair cells, and cochlea when presented with simple acoustic stimuli. In experiment 2, I used behavioral methods to evaluate differences in perception of simple and complex acoustic stimuli before and after TBI. Through these experiments, we found that the auditory system of laboratory mice is susceptible to blast exposures. In the physiological experiment, the magnitude of the response in the ear was reduced and the time it took for this response to peak increased in blasted subjects relative to uninjured controls after the blast. The high frequency sensitivity of mice was extremely elevated after blast exposures in most subjects, resulting in a reduced range of audibility. Interestingly, in the behavioral experiment, many mice were still able to detect a pure tone of the frequency that had elicited no physiological response in experiment 1. Mice could also detect ultrasonic vocalizations and tones spanning their normal hearing range after blast exposures, albeit to a lesser degree than prior to the exposures. These results have implications for the ways in which human hearing is affected following a similar exposure, because audiometry in the clinic often mirrors the behavioral and physiological measurements tested here. The variability in behavioral responses between blasted mice is significant, suggesting that clinical measurements at acute time points may not accurately reflect the hearing abilities of each individual. These experiments are unique because of the comparisons between physiology and behavior, but are also the first studies to examine changes over three months following injury acquisition for individuals exposed to a blast.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/86461"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["cognitive psychology","behavioral psychology","audiology"],"dc:title":["Auditory Function in CBA/CaJ Mice Following Blast-Induced Traumatic Brain Injury (TBI)"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:32Z"}