{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/84110"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/84110","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Translational Control Promotes Oxidative Stress Resistance in the Human Fungal Pathogen Cryptococcus neoformans","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Leipheimer, Jay; 0000-0002-7772-4205"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Panepinto, John","Microbiology and Immunology"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-06-21T15:48:02Z","date_published":"2022-06-21T15:48:02Z","updated_at":"2026-07-27T19:05:30Z","subjects":["molecular biology","microbiology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/84110","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Panepinto, John","Microbiology and Immunology"]},{"key":"dc:creator","label":"Author","values":["Leipheimer, Jay; 0000-0002-7772-4205"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-06-21T15:48:02Z","2020"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["molecular biology","microbiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/84110"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Cryptococcus neoformans is one of the few environmental fungi that can adapt to a mammalian host and cause disease. As free a living organism, C. neoformans is challenged with a variety of environmental insults that threaten its cellular processes. In some cases, these challenges mimic conditions present within mammals resulting in the accidental selection of virulence factors over evolutionary time. Be it within a host or the soil; fungi must contend with environmental challenges through the production of stress effector proteins while maintaining factors that are required for viability in any condition. Although many of the factors responsible for establishing virulence have been recognized, how they are actually expressed in response to certain host-derived cellular stresses is rarely addressed. Earlier work found that many mRNAs encoding ribosomal proteins (RP) are rapidly repressed during cellular stress and that the bulk of this repression is mediated by deadenylation-dependent mRNA decay. We discovered that many of these RP transcripts possessed a motif in their 3’UTRs, GGAUG...The interplay between mRNA translation and decay and its role in pathogenesis in C. neoformans will be outlined in this manuscript.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Translational Control Promotes Oxidative Stress Resistance in the Human Fungal Pathogen Cryptococcus neoformans"]}]}],"canonical_facts":{"dc:contributor":["Panepinto, John","Microbiology and Immunology"],"dc:creator":["Leipheimer, Jay; 0000-0002-7772-4205"],"dc:date":["2022-06-21T15:48:02Z","2020"],"dc:description":["Ph.D.","Cryptococcus neoformans is one of the few environmental fungi that can adapt to a mammalian host and cause disease. As free a living organism, C. neoformans is challenged with a variety of environmental insults that threaten its cellular processes. In some cases, these challenges mimic conditions present within mammals resulting in the accidental selection of virulence factors over evolutionary time. Be it within a host or the soil; fungi must contend with environmental challenges through the production of stress effector proteins while maintaining factors that are required for viability in any condition. Although many of the factors responsible for establishing virulence have been recognized, how they are actually expressed in response to certain host-derived cellular stresses is rarely addressed. Earlier work found that many mRNAs encoding ribosomal proteins (RP) are rapidly repressed during cellular stress and that the bulk of this repression is mediated by deadenylation-dependent mRNA decay. We discovered that many of these RP transcripts possessed a motif in their 3’UTRs, GGAUG...The interplay between mRNA translation and decay and its role in pathogenesis in C. neoformans will be outlined in this manuscript.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/84110"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["molecular biology","microbiology"],"dc:title":["Translational Control Promotes Oxidative Stress Resistance in the Human Fungal Pathogen Cryptococcus neoformans"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:30Z"}