{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/84080"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/84080","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Polymer-Based Nanostructures for Encapsulation, Conjugation, and Therapeutic Delivery","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Jafari, Amin; 0000-0002-0867-745X"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Cheng, Chong","Chemical and Biological Engineering"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-06-21T15:47:43Z","date_published":"2022-06-21T15:47:43Z","updated_at":"2026-07-27T19:05:30Z","subjects":["pharmaceutical sciences","materials science","polymer chemistry"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/84080","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Cheng, Chong","Chemical and Biological Engineering"]},{"key":"dc:creator","label":"Author","values":["Jafari, Amin; 0000-0002-0867-745X"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-06-21T15:47:43Z","2020"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["pharmaceutical sciences","materials science","polymer chemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/84080"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Effective delivery of therapeutic agents, such as free drug molecules and genes, to specific biological sites presents a significant challenge for biomedical researchers. Several biological barriers are hindering the delivery of free therapeutic materials directly to the diseased tissue, such as degradation by serum protein absorption, macrophage internalization, sequestration in the reticuloendothelial system, clearance by the kidney, etc. Over the past decades, nanocarriers have emerged as promising biomaterials that may overcome biological barriers, protect the therapeutic cargo, and effectively deliver them to the diseased tissue. Polymer-based nanocarriers have drawn tremendous interest because of their significant potential to improve therapeutic biocompatibility, solubility, bioavailability, controlled release, and also minimizing therapeutic toxicity, and nonspecific interactions. With a thoughtful structural design, they can exhibit provide biomedical-relevant stimuli-responsive behavior via variables such as pH, light, and temperatures. The formulation of novel polymer-based nanocarriers for therapeutic delivery has been the focus of many researchers over the past decades. Aligned with such a research direction, this dissertation research includes two major projects: 1) nanocapsules preparation by layer-by-layer (LBL) self-assembly, and 2) synthesis and development of multiple polycaprolactone (PCL)-based nanocarriers for drug and gene delivery applications.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Polymer-Based Nanostructures for Encapsulation, Conjugation, and Therapeutic Delivery"]}]}],"canonical_facts":{"dc:contributor":["Cheng, Chong","Chemical and Biological Engineering"],"dc:creator":["Jafari, Amin; 0000-0002-0867-745X"],"dc:date":["2022-06-21T15:47:43Z","2020"],"dc:description":["Ph.D.","Effective delivery of therapeutic agents, such as free drug molecules and genes, to specific biological sites presents a significant challenge for biomedical researchers. Several biological barriers are hindering the delivery of free therapeutic materials directly to the diseased tissue, such as degradation by serum protein absorption, macrophage internalization, sequestration in the reticuloendothelial system, clearance by the kidney, etc. Over the past decades, nanocarriers have emerged as promising biomaterials that may overcome biological barriers, protect the therapeutic cargo, and effectively deliver them to the diseased tissue. Polymer-based nanocarriers have drawn tremendous interest because of their significant potential to improve therapeutic biocompatibility, solubility, bioavailability, controlled release, and also minimizing therapeutic toxicity, and nonspecific interactions. With a thoughtful structural design, they can exhibit provide biomedical-relevant stimuli-responsive behavior via variables such as pH, light, and temperatures. The formulation of novel polymer-based nanocarriers for therapeutic delivery has been the focus of many researchers over the past decades. Aligned with such a research direction, this dissertation research includes two major projects: 1) nanocapsules preparation by layer-by-layer (LBL) self-assembly, and 2) synthesis and development of multiple polycaprolactone (PCL)-based nanocarriers for drug and gene delivery applications.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/84080"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["pharmaceutical sciences","materials science","polymer chemistry"],"dc:title":["Polymer-Based Nanostructures for Encapsulation, Conjugation, and Therapeutic Delivery"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:30Z"}