{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/84064"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/84064","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Indoleamine 2,3-dioxygenase Regulates PD-1 Expression on CD8+ T Cells via Kynurenine Activation of the Aryl Hydrocarbon Receptor","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Amobi-McCloud, Adaobi; 0000-0002-0243-2945"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Odunsi, Adekunle","Roswell Park"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-06-21T15:47:33Z","date_published":"2022-06-21T15:47:33Z","updated_at":"2026-07-27T19:05:30Z","subjects":["immunology","oncology","microbiology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/84064","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Odunsi, Adekunle","Roswell Park"]},{"key":"dc:creator","label":"Author","values":["Amobi-McCloud, Adaobi; 0000-0002-0243-2945"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-06-21T15:47:33Z","2020"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["immunology","oncology","microbiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/84064"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Epithelial ovarian cancer (EOC) is the deadliest gynecologic malignancy in the United States. Despite initial response to surgery and platinum- and taxane-based chemotherapy, the majority of patients relapse and ultimately die from their disease within five years. Work by our group has shown that the presence of intra-epithelial CD8+ tumor-infiltrating lymphocytes is associated with favorable outcomes in EOC patients. However, suppressive mechanisms in the tumor microenvironment inhibit antigen-specific immunity, impacting tumor growth and metastasis. Our group has also shown that tumor-derived antigen-specific CD8+ T cells from ovarian cancer demonstrate impaired effector function and enriched expression of the inhibitory molecule programmed cell death protein 1 (PD-1). Moreover, we demonstrated that expression of the enzyme indoleamine 2,3-dioxygenase (IDO) in ovarian tumor correlates with poor prognosis and poor tumor infiltration by CD8+ T cells. However, a complete understanding of the cellular and molecular mechanisms of IDO-mediated suppression of T cells remains unclear, and is therefore the focus of my thesis work.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Indoleamine 2,3-dioxygenase Regulates PD-1 Expression on CD8+ T Cells via Kynurenine Activation of the Aryl Hydrocarbon Receptor"]}]}],"canonical_facts":{"dc:contributor":["Odunsi, Adekunle","Roswell Park"],"dc:creator":["Amobi-McCloud, Adaobi; 0000-0002-0243-2945"],"dc:date":["2022-06-21T15:47:33Z","2020"],"dc:description":["Ph.D.","Epithelial ovarian cancer (EOC) is the deadliest gynecologic malignancy in the United States. Despite initial response to surgery and platinum- and taxane-based chemotherapy, the majority of patients relapse and ultimately die from their disease within five years. Work by our group has shown that the presence of intra-epithelial CD8+ tumor-infiltrating lymphocytes is associated with favorable outcomes in EOC patients. However, suppressive mechanisms in the tumor microenvironment inhibit antigen-specific immunity, impacting tumor growth and metastasis. Our group has also shown that tumor-derived antigen-specific CD8+ T cells from ovarian cancer demonstrate impaired effector function and enriched expression of the inhibitory molecule programmed cell death protein 1 (PD-1). Moreover, we demonstrated that expression of the enzyme indoleamine 2,3-dioxygenase (IDO) in ovarian tumor correlates with poor prognosis and poor tumor infiltration by CD8+ T cells. However, a complete understanding of the cellular and molecular mechanisms of IDO-mediated suppression of T cells remains unclear, and is therefore the focus of my thesis work.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/84064"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["immunology","oncology","microbiology"],"dc:title":["Indoleamine 2,3-dioxygenase Regulates PD-1 Expression on CD8+ T Cells via Kynurenine Activation of the Aryl Hydrocarbon Receptor"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:30Z"}