{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/84048"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/84048","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Enhancement of Human Gingival Fibroblast Migration by Strontium","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Wali, Rofida"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Visser, Michelle","Oral Sciences"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-06-21T15:47:23Z","date_published":"2022-06-21T15:47:23Z","updated_at":"2026-07-27T19:05:30Z","subjects":["biology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/84048","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Visser, Michelle","Oral Sciences"]},{"key":"dc:creator","label":"Author","values":["Wali, Rofida"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-06-21T15:47:23Z","2020"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["biology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/84048"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","Background: Human gingival fibroblast (HGF) migration is critically important in tissue regeneration and healing. After a dental implant is placed, fibroblasts are primary cells to repopulate the wound, attach to implant abutment, and form a healthy and collagen-rich connective tissue seal. Over the past decades, strontium, which is an alkaline earth metal, has attracted attention owing to its beneficial effects in osteoblast proliferation and osteoporosis treatment. Recently published work has highlighted the potential positive effect on gingival fibroblasts. Aim: The goal of the present study was to evaluate the ability of strontium to enhance fibroblast cells migration and attachment in vitro. Methods: HGF scratch cell migration assays were performed on collagen coated or uncoated cell culture plates. HGFs were exposed to strontium directly in solution or indirectly through conditioned media released from alginate-strontium scaffolds (0%,5%,10%). In addition, cell attachment on strontium alginate coated titanium surfaces was evaluated. Results: A trend for increased cell migration with 1mM(10%) strontium at 48 hours was observed. Cells grown in alginate media or on alginate coated titanium surfaces exhibit changes in their morphology, impaired growth and migration although a small positive effect was observed from strontium. Conclusion: These findings suggest that strontium citrate displays a positive effect on cells migration at 10% concentration with no cytotoxic effect observed. Further research is warranted in this area.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Enhancement of Human Gingival Fibroblast Migration by Strontium"]}]}],"canonical_facts":{"dc:contributor":["Visser, Michelle","Oral Sciences"],"dc:creator":["Wali, Rofida"],"dc:date":["2022-06-21T15:47:23Z","2020"],"dc:description":["M.S.","Background: Human gingival fibroblast (HGF) migration is critically important in tissue regeneration and healing. After a dental implant is placed, fibroblasts are primary cells to repopulate the wound, attach to implant abutment, and form a healthy and collagen-rich connective tissue seal. Over the past decades, strontium, which is an alkaline earth metal, has attracted attention owing to its beneficial effects in osteoblast proliferation and osteoporosis treatment. Recently published work has highlighted the potential positive effect on gingival fibroblasts. Aim: The goal of the present study was to evaluate the ability of strontium to enhance fibroblast cells migration and attachment in vitro. Methods: HGF scratch cell migration assays were performed on collagen coated or uncoated cell culture plates. HGFs were exposed to strontium directly in solution or indirectly through conditioned media released from alginate-strontium scaffolds (0%,5%,10%). In addition, cell attachment on strontium alginate coated titanium surfaces was evaluated. Results: A trend for increased cell migration with 1mM(10%) strontium at 48 hours was observed. Cells grown in alginate media or on alginate coated titanium surfaces exhibit changes in their morphology, impaired growth and migration although a small positive effect was observed from strontium. Conclusion: These findings suggest that strontium citrate displays a positive effect on cells migration at 10% concentration with no cytotoxic effect observed. Further research is warranted in this area.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/84048"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["biology"],"dc:title":["Enhancement of Human Gingival Fibroblast Migration by Strontium"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:30Z"}