{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/83853"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/83853","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Enantioselective Syntheses of Six-Membered Saturated Oxygen Heterocycles via Copper(II)-Catalyzed Carboetherification and Hydroetherification of Unactivated Alkenes","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Berhane, Ilyas; 0000-0002-4979-8055"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Chemler, Sherry","Chemistry"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-06-17T19:54:47Z","date_published":"2022-06-17T19:54:47Z","updated_at":"2026-07-27T19:05:28Z","subjects":["organic chemistry"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/83853","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Chemler, Sherry","Chemistry"]},{"key":"dc:creator","label":"Author","values":["Berhane, Ilyas; 0000-0002-4979-8055"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-06-17T19:54:47Z","2020"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["organic chemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/83853"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","In this dissertation, the enantioselective copper-catalyzed carboetherification and hydroetherification of unactivated alkenes is discussed. These methods enable access to a number of enantioenriched six-membered ring oxygen heterocycles, found in many natural products and bioactive compounds, such as, tetrahydropyrans, dihydropyrans, isochromans, and morpholines. This thesis is divided into two chapters. Chapter one describes the advances in enantioselective carboetherification reactions in their application to five and six-membered ring oxygen heterocycles. Our development of the first enantioselective copper-catalyzed carboetherification and oxidative coupling of alkenols to make six-membered cyclic ethers and its application to a short synthesis of a σ1 receptor ligand is presented. Chapter two discusses our expansion to developing the first enantioselective copper-catalyzed hydroetherification reaction to access six-membered oxygen heterocycles.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Enantioselective Syntheses of Six-Membered Saturated Oxygen Heterocycles via Copper(II)-Catalyzed Carboetherification and Hydroetherification of Unactivated Alkenes"]}]}],"canonical_facts":{"dc:contributor":["Chemler, Sherry","Chemistry"],"dc:creator":["Berhane, Ilyas; 0000-0002-4979-8055"],"dc:date":["2022-06-17T19:54:47Z","2020"],"dc:description":["Ph.D.","In this dissertation, the enantioselective copper-catalyzed carboetherification and hydroetherification of unactivated alkenes is discussed. These methods enable access to a number of enantioenriched six-membered ring oxygen heterocycles, found in many natural products and bioactive compounds, such as, tetrahydropyrans, dihydropyrans, isochromans, and morpholines. This thesis is divided into two chapters. Chapter one describes the advances in enantioselective carboetherification reactions in their application to five and six-membered ring oxygen heterocycles. Our development of the first enantioselective copper-catalyzed carboetherification and oxidative coupling of alkenols to make six-membered cyclic ethers and its application to a short synthesis of a σ1 receptor ligand is presented. Chapter two discusses our expansion to developing the first enantioselective copper-catalyzed hydroetherification reaction to access six-membered oxygen heterocycles.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/83853"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["organic chemistry"],"dc:title":["Enantioselective Syntheses of Six-Membered Saturated Oxygen Heterocycles via Copper(II)-Catalyzed Carboetherification and Hydroetherification of Unactivated Alkenes"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:28Z"}