{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/83836"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/83836","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Inflammatory Factor and Biomarkers for Epithelial Ovarian Cancer","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Alsulimani, Ahmad"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Moysich, Kirsten","Roswell Park"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-06-17T19:54:35Z","date_published":"2022-06-17T19:54:35Z","updated_at":"2026-07-27T19:05:28Z","subjects":["pathology","epidemiology","cancer sciences"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/83836","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Moysich, Kirsten","Roswell Park"]},{"key":"dc:creator","label":"Author","values":["Alsulimani, Ahmad"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-06-17T19:54:35Z","2020"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["pathology","epidemiology","cancer sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/83836"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","While ovarian cancer is the second most common gynecological cancer, it is the fifth leading cause of cancer-related deaths in the US. Due to a lack of adequate screening tools, it is imperative to develop innovative methods to identify women at greater risk of developing invasive epithelial ovarian cancer (EOC). This dissertation had three aims: 1) determine if endometriosis is associated with highly fatal EOC, 2) evaluate the expression of Flotillin 1 (FLOT1) as a marker of clinic pathology and patient outcomes in women with serous EOC, and 3) investigate the prognostic role of programmed death-ligand 1 (PD-L1) and cluster of differentiation 8 (CD8) in clinical outcomes in EOC. This dissertation utilized pooled data from 18 case-control studies participating in the Ovarian Cancer Association Consortium, tissue microarray-based immunohistochemistry from 492 patients diagnosed with EOC who underwent primary surgery at Roswell Park comprehensive Cancer Center, and tissue microarrays from 416 patients diagnosed with invasive EOC to determine these relationships. Women with endometriosis had an increased odds of 12 month highly fatal EOC by 73% (OR= 1.73, 95% CI: 1.18, 2.55) and 18 month highly fatal EOC by 43% (OR=1.43, 95% CI: 1.12, 1.83) compared to women without endometriosis. After histotype stratification, endometriosis was associated with endometrioid (OR=3.04, 95% CI: 1.33, 6.88) and clear cell (OR=2.67, 95% CI: 1.27, 5.58) 12 month highly fatal EOC and endometrioid (OR=2.29, 95% 1.08, 4.84) and clear cell (OR=3.39, 95% CI: 2.19, 5.23) 18 month highly fatal EOC. FLOT1 expression was detected in 346 cases of serous histology. Women with high FLOT1 expression had lower survival probabilities compared to women with lower FLOT1 expression (HR=1.63, 95% CI: 1.31-2.34). High expression of PD-L1 and CD8 was associated with histology, advanced grade and stage, and better overall survival (all p<0.05). High expression of PD-L1 combined with CD8 was associated with better overall survival (HR=0.75, 95% CI: 0.75, 0.99; p=0.03). Our findings support the relationship between endometriosis and highly fatal EOC, particularly in endometrioid and clear cell histotypes. Additionally, FLOT1, PD-L1 and CD8 are potential biomarkers for ovarian cancer."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Inflammatory Factor and Biomarkers for Epithelial Ovarian Cancer"]}]}],"canonical_facts":{"dc:contributor":["Moysich, Kirsten","Roswell Park"],"dc:creator":["Alsulimani, Ahmad"],"dc:date":["2022-06-17T19:54:35Z","2020"],"dc:description":["Ph.D.","While ovarian cancer is the second most common gynecological cancer, it is the fifth leading cause of cancer-related deaths in the US. Due to a lack of adequate screening tools, it is imperative to develop innovative methods to identify women at greater risk of developing invasive epithelial ovarian cancer (EOC). This dissertation had three aims: 1) determine if endometriosis is associated with highly fatal EOC, 2) evaluate the expression of Flotillin 1 (FLOT1) as a marker of clinic pathology and patient outcomes in women with serous EOC, and 3) investigate the prognostic role of programmed death-ligand 1 (PD-L1) and cluster of differentiation 8 (CD8) in clinical outcomes in EOC. This dissertation utilized pooled data from 18 case-control studies participating in the Ovarian Cancer Association Consortium, tissue microarray-based immunohistochemistry from 492 patients diagnosed with EOC who underwent primary surgery at Roswell Park comprehensive Cancer Center, and tissue microarrays from 416 patients diagnosed with invasive EOC to determine these relationships. Women with endometriosis had an increased odds of 12 month highly fatal EOC by 73% (OR= 1.73, 95% CI: 1.18, 2.55) and 18 month highly fatal EOC by 43% (OR=1.43, 95% CI: 1.12, 1.83) compared to women without endometriosis. After histotype stratification, endometriosis was associated with endometrioid (OR=3.04, 95% CI: 1.33, 6.88) and clear cell (OR=2.67, 95% CI: 1.27, 5.58) 12 month highly fatal EOC and endometrioid (OR=2.29, 95% 1.08, 4.84) and clear cell (OR=3.39, 95% CI: 2.19, 5.23) 18 month highly fatal EOC. FLOT1 expression was detected in 346 cases of serous histology. Women with high FLOT1 expression had lower survival probabilities compared to women with lower FLOT1 expression (HR=1.63, 95% CI: 1.31-2.34). High expression of PD-L1 and CD8 was associated with histology, advanced grade and stage, and better overall survival (all p<0.05). High expression of PD-L1 combined with CD8 was associated with better overall survival (HR=0.75, 95% CI: 0.75, 0.99; p=0.03). Our findings support the relationship between endometriosis and highly fatal EOC, particularly in endometrioid and clear cell histotypes. Additionally, FLOT1, PD-L1 and CD8 are potential biomarkers for ovarian cancer."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/83836"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["pathology","epidemiology","cancer sciences"],"dc:title":["Inflammatory Factor and Biomarkers for Epithelial Ovarian Cancer"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:28Z"}