{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/83834"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/83834","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Sex Hormone Regulation of Immune Responses: The Impact of Androgen Receptor in Myeloid Cell Function","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Consiglio, Camila; 0000-0002-8901-2328"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Gollnick, Sandra","Microbiology and Immunology"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-06-17T19:54:34Z","date_published":"2022-06-17T19:54:34Z","updated_at":"2026-07-27T19:05:28Z","subjects":["immunology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/83834","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gollnick, Sandra","Microbiology and Immunology"]},{"key":"dc:creator","label":"Author","values":["Consiglio, Camila; 0000-0002-8901-2328"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-06-17T19:54:34Z","2020"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["immunology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/83834"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","The immune system is a complex system that combines cellular and soluble mediators that recognize numerous microorganisms and destroys pathogens. Although the immune system has evolved to defend the organism against invading pathogens, immune cells are also implicated and deregulated in various disease states. It is increasingly recognized that men and women display differences in disease susceptibility, prevalence and pathogenesis. These include sex disparity in cancer, autoimmunity, allergy and infectious diseases. While the etiology of these diseases differs significantly, their pathogenesis is tightly linked to the immune system. In general, women show enhanced, while men display weaker immune responses. Testosterone has generally been associated with an immunosuppressive effect, while estrogen enhances immune responses. Sex differences in immune responses and disease susceptibility highlight the importance of studying how immune function is regulated by sex hormone signaling, to ultimately understand and treat disease. Here we demonstrate for the first time that androgen receptor (AR) antagonism, a commonly used treatment for prostate cancer, induces functional and metabolic changes in myeloid cells associated with increased immunosuppression and tumor progression (Chapter 2). We further show that sex hormone modulation, such as reducing the ratio of estradiol to testosterone signaling, impairs clearance of urinary tract infection in female mice (Chapter 3). Moreover, we identify that AR is required for monocytic differentiation in the bone marrow (Chapter 4). Finally, we demonstrate that myeloid AR expression impacts T cell development in the thymus (Chapter 5). Our studies add to the growing evidence that sex hormones impact immunity, and that sex hormone manipulations affect the course of diseases."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Sex Hormone Regulation of Immune Responses: The Impact of Androgen Receptor in Myeloid Cell Function"]}]}],"canonical_facts":{"dc:contributor":["Gollnick, Sandra","Microbiology and Immunology"],"dc:creator":["Consiglio, Camila; 0000-0002-8901-2328"],"dc:date":["2022-06-17T19:54:34Z","2020"],"dc:description":["Ph.D.","The immune system is a complex system that combines cellular and soluble mediators that recognize numerous microorganisms and destroys pathogens. Although the immune system has evolved to defend the organism against invading pathogens, immune cells are also implicated and deregulated in various disease states. It is increasingly recognized that men and women display differences in disease susceptibility, prevalence and pathogenesis. These include sex disparity in cancer, autoimmunity, allergy and infectious diseases. While the etiology of these diseases differs significantly, their pathogenesis is tightly linked to the immune system. In general, women show enhanced, while men display weaker immune responses. Testosterone has generally been associated with an immunosuppressive effect, while estrogen enhances immune responses. Sex differences in immune responses and disease susceptibility highlight the importance of studying how immune function is regulated by sex hormone signaling, to ultimately understand and treat disease. Here we demonstrate for the first time that androgen receptor (AR) antagonism, a commonly used treatment for prostate cancer, induces functional and metabolic changes in myeloid cells associated with increased immunosuppression and tumor progression (Chapter 2). We further show that sex hormone modulation, such as reducing the ratio of estradiol to testosterone signaling, impairs clearance of urinary tract infection in female mice (Chapter 3). Moreover, we identify that AR is required for monocytic differentiation in the bone marrow (Chapter 4). Finally, we demonstrate that myeloid AR expression impacts T cell development in the thymus (Chapter 5). Our studies add to the growing evidence that sex hormones impact immunity, and that sex hormone manipulations affect the course of diseases."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/83834"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["immunology"],"dc:title":["Sex Hormone Regulation of Immune Responses: The Impact of Androgen Receptor in Myeloid Cell Function"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:28Z"}