{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/80961"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/80961","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Modulation of Vestibular Efferents and Its Impact on Afferent Signalling in Live Animals","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Raghu, Vishal"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Sadeghi, Soroush","Neuroscience"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-10-29T16:48:31Z","date_published":"2019-10-29T16:48:31Z","updated_at":"2026-07-27T19:05:28Z","subjects":["neurosciences"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/80961","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Sadeghi, Soroush","Neuroscience"]},{"key":"dc:creator","label":"Author","values":["Raghu, Vishal"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-10-29T16:48:31Z","2019","2019-08-29 01:00:44"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["neurosciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/80961"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","The vestibular organs convey information about head tilt and movements to the brainstem and the cerebellum and control or influence powerful and fast reflexes, which allow us to maintain gaze and balance. The first stages of sensing happen in the three semicircular canals, which sense angular motion and the two otolith organs –the utricle and the saccule, which sense horizontal motion and vertical linear motions respectively. Vestibular afferent neurons can be broadly classified as regularly firing and irregularly firing based on their resting discharges. Irregular neurons form an important part of the phasic arc of the vestibular system that carries and processes information about high-frequency head motionsThe vestibular periphery is also targeted by efferent feedback originating from the brainstem. While much is yet unknown about the exact nature of efferet-mediated modulations of hair cells and afferents, studying afferent properties via stimulation of efferent neurons have unearthed some important information about them. Broadly speaking, efferent-mediated afferent responses have the following characteristics in mammals: (i) efferent stimulation causes excitation in afferents (Marlinski et al., 2004), (ii) the responses consist of fast and slow components (iii) efferent stimulation lowers gains of afferent responses to movement (iv) the responses are more prominent in irregular afferents than in regular afferents, and (v) Strong head movements stimulate efferents which in turn reflect in afferent activity bilaterally. Efferents also play vitally important roles in mechanisms involved in vestibular plasticity such as compensation and adaptation, and it is believed that this happens via the influence efferents exert on the irregular/ phasic pathways in the vestibular system.To thoroughly gain a deeper understanding of efferent action, it is necessary to study the independent functioning of both afferent and efferent neurons and the molecular signalling characteristics between efferents and their targets in a compartmentalized manner."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Modulation of Vestibular Efferents and Its Impact on Afferent Signalling in Live Animals"]}]}],"canonical_facts":{"dc:contributor":["Sadeghi, Soroush","Neuroscience"],"dc:creator":["Raghu, Vishal"],"dc:date":["2019-10-29T16:48:31Z","2019","2019-08-29 01:00:44"],"dc:description":["Ph.D.","The vestibular organs convey information about head tilt and movements to the brainstem and the cerebellum and control or influence powerful and fast reflexes, which allow us to maintain gaze and balance. The first stages of sensing happen in the three semicircular canals, which sense angular motion and the two otolith organs –the utricle and the saccule, which sense horizontal motion and vertical linear motions respectively. Vestibular afferent neurons can be broadly classified as regularly firing and irregularly firing based on their resting discharges. Irregular neurons form an important part of the phasic arc of the vestibular system that carries and processes information about high-frequency head motionsThe vestibular periphery is also targeted by efferent feedback originating from the brainstem. While much is yet unknown about the exact nature of efferet-mediated modulations of hair cells and afferents, studying afferent properties via stimulation of efferent neurons have unearthed some important information about them. Broadly speaking, efferent-mediated afferent responses have the following characteristics in mammals: (i) efferent stimulation causes excitation in afferents (Marlinski et al., 2004), (ii) the responses consist of fast and slow components (iii) efferent stimulation lowers gains of afferent responses to movement (iv) the responses are more prominent in irregular afferents than in regular afferents, and (v) Strong head movements stimulate efferents which in turn reflect in afferent activity bilaterally. Efferents also play vitally important roles in mechanisms involved in vestibular plasticity such as compensation and adaptation, and it is believed that this happens via the influence efferents exert on the irregular/ phasic pathways in the vestibular system.To thoroughly gain a deeper understanding of efferent action, it is necessary to study the independent functioning of both afferent and efferent neurons and the molecular signalling characteristics between efferents and their targets in a compartmentalized manner."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/80961"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["neurosciences"],"dc:title":["Modulation of Vestibular Efferents and Its Impact on Afferent Signalling in Live Animals"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:28Z"}