{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/80960"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/80960","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Surface Neuritin Expression Primarily Marks a Unique Activated Subpopulation of Regulatory T Cells in the Melanoma Setting","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Sharda, Baiju; 0000-0003-3409-3631"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Barbi, Joseph","Roswell Park"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-10-29T16:48:31Z","date_published":"2019-10-29T16:48:31Z","updated_at":"2026-07-27T19:05:28Z","subjects":["cellular biology","immunology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/80960","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Barbi, Joseph","Roswell Park"]},{"key":"dc:creator","label":"Author","values":["Sharda, Baiju; 0000-0003-3409-3631"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-10-29T16:48:31Z","2019","2019-08-11 22:14:28"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["cellular biology","immunology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/80960"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","The uncontrolled proliferation of a somatic cell into a tumor that is capable of invasion and metastases is a complicated process that requires the failure of multiple protective measures that have evolved over millions of years. Over the past several decades, there has been prolific data on the importance of the immune system in deterring the development of a tumor. The heterogeneous population of immune cells are in a constant surveillance for the destruction of potential precancerous cells; however, there exists a suppressive subset of T cells, called regulatory T cells (Tregs), which can undermine immune cells with anti-tumor potential. To date, there is a severe lack of reliable, targetable surface molecules that can be used to antagonize Tregs in the context of cancer; this poses a challenge to clinicians for treating patients with tumors that are highly Treg dependent. Molecules that have been proposed for targeting, such as CD25, are not exclusive to Tregs and targeting them can lead to undesirable off-target effects, such as the depletion of T cells with potential of eradicating tumors. In the search for novel surface molecules, Barbi and Pardoll have discovered a small, glycosylphosphatidylinisotol-anchored protein called Neuritin, on the surface of Tregs. Surface expression of Neuritin on Tregs has characterized these cells as more potent immunosuppressors and Neuritin may emerge as an important immunomodulatory factor, necessary for Treg-mediated suppression."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Surface Neuritin Expression Primarily Marks a Unique Activated Subpopulation of Regulatory T Cells in the Melanoma Setting"]}]}],"canonical_facts":{"dc:contributor":["Barbi, Joseph","Roswell Park"],"dc:creator":["Sharda, Baiju; 0000-0003-3409-3631"],"dc:date":["2019-10-29T16:48:31Z","2019","2019-08-11 22:14:28"],"dc:description":["M.S.","The uncontrolled proliferation of a somatic cell into a tumor that is capable of invasion and metastases is a complicated process that requires the failure of multiple protective measures that have evolved over millions of years. Over the past several decades, there has been prolific data on the importance of the immune system in deterring the development of a tumor. The heterogeneous population of immune cells are in a constant surveillance for the destruction of potential precancerous cells; however, there exists a suppressive subset of T cells, called regulatory T cells (Tregs), which can undermine immune cells with anti-tumor potential. To date, there is a severe lack of reliable, targetable surface molecules that can be used to antagonize Tregs in the context of cancer; this poses a challenge to clinicians for treating patients with tumors that are highly Treg dependent. Molecules that have been proposed for targeting, such as CD25, are not exclusive to Tregs and targeting them can lead to undesirable off-target effects, such as the depletion of T cells with potential of eradicating tumors. In the search for novel surface molecules, Barbi and Pardoll have discovered a small, glycosylphosphatidylinisotol-anchored protein called Neuritin, on the surface of Tregs. Surface expression of Neuritin on Tregs has characterized these cells as more potent immunosuppressors and Neuritin may emerge as an important immunomodulatory factor, necessary for Treg-mediated suppression."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/80960"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["cellular biology","immunology"],"dc:title":["Surface Neuritin Expression Primarily Marks a Unique Activated Subpopulation of Regulatory T Cells in the Melanoma Setting"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:28Z"}