{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/80959"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/80959","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Potential Application of nanoCalcium Sulfate-BioDentine Composite as a Bone Regenerative Material","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Sheth, Bhoomika; 0000-0002-9366-9664"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Swihart, Mark","Chemical and Biological Engineering"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-10-29T16:48:30Z","date_published":"2019-10-29T16:48:30Z","updated_at":"2026-07-27T19:05:28Z","subjects":["nanotechnology","chemical engineering"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/80959","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Swihart, Mark","Chemical and Biological Engineering"]},{"key":"dc:creator","label":"Author","values":["Sheth, Bhoomika; 0000-0002-9366-9664"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-10-29T16:48:30Z","2019","2019-08-10 03:30:32"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["nanotechnology","chemical engineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/80959"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","Bones, the scaffold of the human body, are composed of organic and inorganic components, with a hierarchical structure ranging from the nanoscale to the macroscale. Nanomaterials mimicking the features of bone and offering unique smart functions provide promising new strategies for bone regeneration and repair. Calcium sulfate, e.g. plaster of Paris, has been used in dentistry for over 100 years, and possesses advantageous properties, such as rapid setting time, good biocompatibility, and moderate X-ray radiopacity. However, its low mechanical strength, relatively rapid resorption, and perceived lack of bioactivity have limited its wider clinical applications. Nanoscale calcium sulfate (nCS) shows improved performance relative to conventional calcium sulfate. Introduction of reinforcement particulates with high bioactivity and moderate degradability into nCS can be an effective approach to overcome its remaining limitations. Bearing this in mind, we developed a nCS-based composite incorporating tricalcium silicate (Ca3SiO5 or C3S) and showed that the composite material exhibited superior mechanical strength compared with pure nCS. More importantly, we found that the degradation rate of nCS was significantly reduced by the addition of C3S. The enhanced self-setting properties and improved in vitro biological performance of the composite material is due to the fact that both nCS and C3S can be hydrated to produce a rigid solid from a powder. The hydration product of C3S possesses higher mechanical strength and lower degradability than that of nCS. These findings indicated that the incorporation of C3S into nCS could be an effective approach to improve the clinical performance of nCS-based bone graft materials, and suggest that this approach is worthy of further in vitro and in vivo evaluation. To test this theory, a comparison was drawn between the nCS-CS3 cement and a cement of nCS and Biodentine. Biodentine is a calcium-silicate based material that is commercially available and is used in various clinical applications in dentistry as a permanent (non-resorbable) bone cement. The aim of the present study is to prepare nano calcium sulfate–Biodentine composites and to investigate their setting time, mechanical properties, and degradability. The performance of our proposed cement is compared with the pure nano calcium sulfate–tricalcium silicate material synthesized in our lab with respect to these properties. We found that the prepared composite cements had superior mechanical strength, faster setting time, better hardness slower dissociation and release of calcium ions compared to pure nano calcium sulfate."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Potential Application of nanoCalcium Sulfate-BioDentine Composite as a Bone Regenerative Material"]}]}],"canonical_facts":{"dc:contributor":["Swihart, Mark","Chemical and Biological Engineering"],"dc:creator":["Sheth, Bhoomika; 0000-0002-9366-9664"],"dc:date":["2019-10-29T16:48:30Z","2019","2019-08-10 03:30:32"],"dc:description":["M.S.","Bones, the scaffold of the human body, are composed of organic and inorganic components, with a hierarchical structure ranging from the nanoscale to the macroscale. Nanomaterials mimicking the features of bone and offering unique smart functions provide promising new strategies for bone regeneration and repair. Calcium sulfate, e.g. plaster of Paris, has been used in dentistry for over 100 years, and possesses advantageous properties, such as rapid setting time, good biocompatibility, and moderate X-ray radiopacity. However, its low mechanical strength, relatively rapid resorption, and perceived lack of bioactivity have limited its wider clinical applications. Nanoscale calcium sulfate (nCS) shows improved performance relative to conventional calcium sulfate. Introduction of reinforcement particulates with high bioactivity and moderate degradability into nCS can be an effective approach to overcome its remaining limitations. Bearing this in mind, we developed a nCS-based composite incorporating tricalcium silicate (Ca3SiO5 or C3S) and showed that the composite material exhibited superior mechanical strength compared with pure nCS. More importantly, we found that the degradation rate of nCS was significantly reduced by the addition of C3S. The enhanced self-setting properties and improved in vitro biological performance of the composite material is due to the fact that both nCS and C3S can be hydrated to produce a rigid solid from a powder. The hydration product of C3S possesses higher mechanical strength and lower degradability than that of nCS. These findings indicated that the incorporation of C3S into nCS could be an effective approach to improve the clinical performance of nCS-based bone graft materials, and suggest that this approach is worthy of further in vitro and in vivo evaluation. To test this theory, a comparison was drawn between the nCS-CS3 cement and a cement of nCS and Biodentine. Biodentine is a calcium-silicate based material that is commercially available and is used in various clinical applications in dentistry as a permanent (non-resorbable) bone cement. The aim of the present study is to prepare nano calcium sulfate–Biodentine composites and to investigate their setting time, mechanical properties, and degradability. The performance of our proposed cement is compared with the pure nano calcium sulfate–tricalcium silicate material synthesized in our lab with respect to these properties. We found that the prepared composite cements had superior mechanical strength, faster setting time, better hardness slower dissociation and release of calcium ions compared to pure nano calcium sulfate."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/80959"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["nanotechnology","chemical engineering"],"dc:title":["Potential Application of nanoCalcium Sulfate-BioDentine Composite as a Bone Regenerative Material"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:28Z"}