{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/80950"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/80950","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Kinetic Modeling of the Molecular Probe 18F-FHBG for Improved PET Reporter Gene Imaging of Stem Cell Therapy","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Dickman, Zachary; 0000-0003-4570-8486"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Parashurama, Natesh","Chemical and Biological Engineering"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-10-29T16:48:26Z","date_published":"2019-10-29T16:48:26Z","updated_at":"2026-07-27T19:05:28Z","subjects":["chemical engineering"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/80950","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Parashurama, Natesh","Chemical and Biological Engineering"]},{"key":"dc:creator","label":"Author","values":["Dickman, Zachary; 0000-0003-4570-8486"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-10-29T16:48:26Z","2019","2019-08-09 15:25:17"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["chemical engineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/80950"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","Imaging by positron emission tomography (PET) has been used for about forty years as an effective tool in the imaging of cancer. This powerful imaging modality now has many uses, both proposed and in practice, in other medical areas. One of these is the relatively new field of regenerative medicine, regeneration of organs or tissues damaged by chronic conditions such as diabetes or liver disease. Often, regenerative medicine depends on cell therapy to achieve its goals and molecular imaging is the only effective way to quantify the resulting data. Molecular imaging includes PET, but the traditional methods of using PET are focused mainly on imaging of cancer. Cell therapy has generally relied on a different type of molecular imaging – optical. Optical imaging involves placing genes (reporter genes) that control bioluminescence or fluorescence in certain organisms into cells that do not contain them. Coupled with cell therapy, measurement of the cells’ expression of added therapeutic gene can be performed by measurement of light produced through bioluminescence or fluorescence. The drawback of optical imaging is that it does not work in deep tissue and therefore will not work in patients. PET, as the name tomography suggests, does not have this issue and will work at any depth."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Kinetic Modeling of the Molecular Probe 18F-FHBG for Improved PET Reporter Gene Imaging of Stem Cell Therapy"]}]}],"canonical_facts":{"dc:contributor":["Parashurama, Natesh","Chemical and Biological Engineering"],"dc:creator":["Dickman, Zachary; 0000-0003-4570-8486"],"dc:date":["2019-10-29T16:48:26Z","2019","2019-08-09 15:25:17"],"dc:description":["M.S.","Imaging by positron emission tomography (PET) has been used for about forty years as an effective tool in the imaging of cancer. This powerful imaging modality now has many uses, both proposed and in practice, in other medical areas. One of these is the relatively new field of regenerative medicine, regeneration of organs or tissues damaged by chronic conditions such as diabetes or liver disease. Often, regenerative medicine depends on cell therapy to achieve its goals and molecular imaging is the only effective way to quantify the resulting data. Molecular imaging includes PET, but the traditional methods of using PET are focused mainly on imaging of cancer. Cell therapy has generally relied on a different type of molecular imaging – optical. Optical imaging involves placing genes (reporter genes) that control bioluminescence or fluorescence in certain organisms into cells that do not contain them. Coupled with cell therapy, measurement of the cells’ expression of added therapeutic gene can be performed by measurement of light produced through bioluminescence or fluorescence. The drawback of optical imaging is that it does not work in deep tissue and therefore will not work in patients. PET, as the name tomography suggests, does not have this issue and will work at any depth."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/80950"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["chemical engineering"],"dc:title":["Kinetic Modeling of the Molecular Probe 18F-FHBG for Improved PET Reporter Gene Imaging of Stem Cell Therapy"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:28Z"}