{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/80861"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/80861","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Dysregulated Lipid Metabolism in Mouse Progeny Born to Hypercholesterolemic Mothers","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Huang, Sze-chi"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Rideout, Todd","Exercise and Nutrition Sciences"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-10-29T16:47:38Z","date_published":"2019-10-29T16:47:38Z","updated_at":"2026-07-27T19:05:25Z","subjects":["nutrition"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/80861","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Rideout, Todd","Exercise and Nutrition Sciences"]},{"key":"dc:creator","label":"Author","values":["Huang, Sze-chi"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-10-29T16:47:38Z","2019","2019-07-24 11:02:27"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["nutrition"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/80861"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","OBJECTIVE: Maternal hypercholesterolemia can alter early fetal development pathways to program hepatic dysfunction such as non-alcoholic fatty liver disease (NAFLD). However, the mechanisms underlying alterations in hepatic lipid deposition in response to early cholesterol exposure are not understood. Therefore, using a diet-induced hypercholesterolemic mouse model, this study characterized alterations in blood and hepatic lipid metabolism in offspring born to hypercholesterolemic mothers. METHODS: Twelve, 2-month old female C57BL6/J mice were randomly assigned to two diets throughout gestation and lactation (n=6/group): Control diet (CON) or a cholesterol-enriched diet (CH; 0.15%) to induce hypercholesterolemia. Offspring at weaning [postnatal day (PND 21)] and adulthood (PND 84) were examined for serum and liver lipid profiling and assessment of hepatic triglyceride (TG) secretion and postprandial lipid clearance following a fat tolerance test. RESULTS: Serum lipids (TC, HDL-C, LDL-C) did not differ (p≥0.05) in newly-weaned and adult offspring from either group, however, higher serum TG (p≤0.05) were observed in adult pups from CH dams. Additionally, both newly-weaned pups and adult offspring from CH dams demonstrated an increase (p≤0.05) in very low-density lipoprotein (VLDL) particle number, VLDL size, and hepatic TG deposition. However, changes in the profile of blood and liver lipids in response to excessive cholesterol exposure were not associated (p≥0.05) with alterations in hepatic TG secretion or postprandial lipid clearance. CONCLUSIONS: Result suggests that maternal hypercholesteremia alters serum triglyceride and triglyceride-rich lipoprotein metabolism and induces hepatic fat deposition in young and mature offspring."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Dysregulated Lipid Metabolism in Mouse Progeny Born to Hypercholesterolemic Mothers"]}]}],"canonical_facts":{"dc:contributor":["Rideout, Todd","Exercise and Nutrition Sciences"],"dc:creator":["Huang, Sze-chi"],"dc:date":["2019-10-29T16:47:38Z","2019","2019-07-24 11:02:27"],"dc:description":["M.S.","OBJECTIVE: Maternal hypercholesterolemia can alter early fetal development pathways to program hepatic dysfunction such as non-alcoholic fatty liver disease (NAFLD). However, the mechanisms underlying alterations in hepatic lipid deposition in response to early cholesterol exposure are not understood. Therefore, using a diet-induced hypercholesterolemic mouse model, this study characterized alterations in blood and hepatic lipid metabolism in offspring born to hypercholesterolemic mothers. METHODS: Twelve, 2-month old female C57BL6/J mice were randomly assigned to two diets throughout gestation and lactation (n=6/group): Control diet (CON) or a cholesterol-enriched diet (CH; 0.15%) to induce hypercholesterolemia. Offspring at weaning [postnatal day (PND 21)] and adulthood (PND 84) were examined for serum and liver lipid profiling and assessment of hepatic triglyceride (TG) secretion and postprandial lipid clearance following a fat tolerance test. RESULTS: Serum lipids (TC, HDL-C, LDL-C) did not differ (p≥0.05) in newly-weaned and adult offspring from either group, however, higher serum TG (p≤0.05) were observed in adult pups from CH dams. Additionally, both newly-weaned pups and adult offspring from CH dams demonstrated an increase (p≤0.05) in very low-density lipoprotein (VLDL) particle number, VLDL size, and hepatic TG deposition. However, changes in the profile of blood and liver lipids in response to excessive cholesterol exposure were not associated (p≥0.05) with alterations in hepatic TG secretion or postprandial lipid clearance. CONCLUSIONS: Result suggests that maternal hypercholesteremia alters serum triglyceride and triglyceride-rich lipoprotein metabolism and induces hepatic fat deposition in young and mature offspring."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/80861"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["nutrition"],"dc:title":["Dysregulated Lipid Metabolism in Mouse Progeny Born to Hypercholesterolemic Mothers"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:25Z"}