{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/80747"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/80747","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"In-Vivo Efficacy of Environmental Chemical & Novel Type Preferring Ligands at SCN Melatonin Receptors in Models of Chronobiological Behaviors","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Glatfelter, Grant; 0000-0003-1011-9083"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Dubocovich, Margarita","Pharmacology and Toxicology"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-10-29T15:27:27Z","date_published":"2019-10-29T15:27:27Z","updated_at":"2026-07-27T19:05:23Z","subjects":["pharmacology","toxicology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/80747","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Dubocovich, Margarita","Pharmacology and Toxicology"]},{"key":"dc:creator","label":"Author","values":["Glatfelter, Grant; 0000-0003-1011-9083"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-10-29T15:27:27Z","2019","2019-08-08 11:34:00"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["pharmacology","toxicology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/80747"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","The goal of the present research was to investigate efficacy of environmental chemical and novel type preferring melatonin receptor ligands utilizing in-vivo rodent models of chronobiological behaviors. Environmental chemical and novel type preferring compounds tested were previously identified using in-silico molecular modeling and screening strategies using ultra large libraries for docking predictions based on receptor models as well as crystal structures of MT1 & MT2 melatonin receptors. Compounds analyzed were also previously tested in-vitro for affinity and canonical signaling through melatonin receptors to predict in-vivo responses in circadian models of behavior sensitive to melatonin receptor compounds. Environmental chemicals (carbamate insecticides, phthalate plasticizers) acting on melatonin receptors have recently been discovered and described by our team. Epidemiological data regarding exposure to these compounds suggests that melatonin receptors may be relevant to unexplained disease pathologies linked to consequences of circadian disturbances. Therefore the ability for several molecules from two classes of environmental compounds shown to interact with melatonin receptors (carbamate insecticides, phthalate plasticizers) were tested for their ability to compete for endogenous melatonin receptors in the suprachiasmatic nucleus of the hypothalamus (SCN), paraventricular nucleus of the thalamus (PVNT), and the pars tuberalis (PT)."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["In-Vivo Efficacy of Environmental Chemical & Novel Type Preferring Ligands at SCN Melatonin Receptors in Models of Chronobiological Behaviors"]}]}],"canonical_facts":{"dc:contributor":["Dubocovich, Margarita","Pharmacology and Toxicology"],"dc:creator":["Glatfelter, Grant; 0000-0003-1011-9083"],"dc:date":["2019-10-29T15:27:27Z","2019","2019-08-08 11:34:00"],"dc:description":["Ph.D.","The goal of the present research was to investigate efficacy of environmental chemical and novel type preferring melatonin receptor ligands utilizing in-vivo rodent models of chronobiological behaviors. Environmental chemical and novel type preferring compounds tested were previously identified using in-silico molecular modeling and screening strategies using ultra large libraries for docking predictions based on receptor models as well as crystal structures of MT1 & MT2 melatonin receptors. Compounds analyzed were also previously tested in-vitro for affinity and canonical signaling through melatonin receptors to predict in-vivo responses in circadian models of behavior sensitive to melatonin receptor compounds. Environmental chemicals (carbamate insecticides, phthalate plasticizers) acting on melatonin receptors have recently been discovered and described by our team. Epidemiological data regarding exposure to these compounds suggests that melatonin receptors may be relevant to unexplained disease pathologies linked to consequences of circadian disturbances. Therefore the ability for several molecules from two classes of environmental compounds shown to interact with melatonin receptors (carbamate insecticides, phthalate plasticizers) were tested for their ability to compete for endogenous melatonin receptors in the suprachiasmatic nucleus of the hypothalamus (SCN), paraventricular nucleus of the thalamus (PVNT), and the pars tuberalis (PT)."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/80747"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["pharmacology","toxicology"],"dc:title":["In-Vivo Efficacy of Environmental Chemical & Novel Type Preferring Ligands at SCN Melatonin Receptors in Models of Chronobiological Behaviors"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:23Z"}