{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/80709"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/80709","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Vascular Tissue Engineering: Harnessing the Body's Regenerative Potential","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Smith Jr., Randall; 0000-0001-8114-3086"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Andreadis, Stelios","Biomedical Engineering"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-10-29T14:22:44Z","date_published":"2019-10-29T14:22:44Z","updated_at":"2026-07-27T19:05:23Z","subjects":["biomedical engineering","cellular biology","bioengineering"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/80709","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Andreadis, Stelios","Biomedical Engineering"]},{"key":"dc:creator","label":"Author","values":["Smith Jr., Randall; 0000-0001-8114-3086"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-10-29T14:22:44Z","2019","2019-08-08 13:04:58"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["biomedical engineering","cellular biology","bioengineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/80709"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Cardiovascular disease is the leading cause of death world-wide, with an estimated 17.9 million deaths in 2016. Therefore, the need for vascular tissue is at the forefront of tissue engineering endeavors. In this dissertation the ability of the body’s regenerative potential will be put to the test. Endothelial cells are a crucial component of vascular tissue and it is increasingly recognized that the immune system, in specific, the monocytes and their activated state, macrophages are just as crucial to the development of blood vessels. In this dissertation studies assessing the ability of vascular endothelial growth factor (VEGF) to capture cells and thereby induce regeneration of vascular tissue will be assessed. Furthermore, monocytes and their active state macrophages will be critically examined as a possible method of regenerating vascular tissue in-vitro and in-situ in both small and large animal models. Additionally, an example of harnessing the body’s regenerative capacity is demonstrated in tissue that relies on angiogenesis for full regeneration. All the studies presented herein demonstrate the remarkable ability of the human body to regenerate tissue when provided with the right biological cues.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Vascular Tissue Engineering: Harnessing the Body's Regenerative Potential"]}]}],"canonical_facts":{"dc:contributor":["Andreadis, Stelios","Biomedical Engineering"],"dc:creator":["Smith Jr., Randall; 0000-0001-8114-3086"],"dc:date":["2019-10-29T14:22:44Z","2019","2019-08-08 13:04:58"],"dc:description":["Ph.D.","Cardiovascular disease is the leading cause of death world-wide, with an estimated 17.9 million deaths in 2016. Therefore, the need for vascular tissue is at the forefront of tissue engineering endeavors. In this dissertation the ability of the body’s regenerative potential will be put to the test. Endothelial cells are a crucial component of vascular tissue and it is increasingly recognized that the immune system, in specific, the monocytes and their activated state, macrophages are just as crucial to the development of blood vessels. In this dissertation studies assessing the ability of vascular endothelial growth factor (VEGF) to capture cells and thereby induce regeneration of vascular tissue will be assessed. Furthermore, monocytes and their active state macrophages will be critically examined as a possible method of regenerating vascular tissue in-vitro and in-situ in both small and large animal models. Additionally, an example of harnessing the body’s regenerative capacity is demonstrated in tissue that relies on angiogenesis for full regeneration. All the studies presented herein demonstrate the remarkable ability of the human body to regenerate tissue when provided with the right biological cues.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/80709"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["biomedical engineering","cellular biology","bioengineering"],"dc:title":["Vascular Tissue Engineering: Harnessing the Body's Regenerative Potential"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:23Z"}