{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/80448"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/80448","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"New Strategies to Enhance Immunotoxin Potency and Anti-Cancer Efficacy","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Polli, Joseph; 0000-0002-2703-1590"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Balthasar, Joseph","Pharmaceutical Sciences"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-10-24T19:35:18Z","date_published":"2019-10-24T19:35:18Z","updated_at":"2026-07-27T19:05:23Z","subjects":["pharmaceutical sciences"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. 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Preliminary evaluation of the CAR-bomb strategy in vivo showed great potential for future applications of this approach."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["New Strategies to Enhance Immunotoxin Potency and Anti-Cancer Efficacy"]}]}],"canonical_facts":{"dc:contributor":["Balthasar, Joseph","Pharmaceutical Sciences"],"dc:creator":["Polli, Joseph; 0000-0002-2703-1590"],"dc:date":["2019-10-24T19:35:18Z","2019","2019-08-09 09:48:20"],"dc:description":["Ph.D.","The presented dissertation highlights development of immunoconjugate strategies that aim to deliver selectively and safely macromolecular toxins to treat colorectal cancer. Experimental observations and mathematical modeling provide pharmacokinetic support to employ CAR mAbs for delivery of macromolecular toxins. In addition, a novel EEP immunoconjugate was generated using Cu2+-free click chemistry and the cleavable vc-PABC peptide linker, and the conjugate was shown to enable a substantial increase in gelonin potency in vitro. Preliminary evaluation of the CAR-bomb strategy in vivo showed great potential for future applications of this approach."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/80448"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["pharmaceutical sciences"],"dc:title":["New Strategies to Enhance Immunotoxin Potency and Anti-Cancer Efficacy"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:23Z"}