{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/80029"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/80029","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Electronic Compensation to Deliver a Total Body Radiation Dose","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Tyson, Tara"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Wang, Zhou (Iris)","Radiology"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-07-30T15:11:58Z","date_published":"2019-07-30T15:11:58Z","updated_at":"2026-07-27T19:05:23Z","subjects":["applied physics"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/80029","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Wang, Zhou (Iris)","Radiology"]},{"key":"dc:creator","label":"Author","values":["Tyson, Tara"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-07-30T15:11:58Z","2019","2019-05-17 15:54:42"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["applied physics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/80029"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Total body irradiation (TBI) is a radiation therapy technique used to suppress a patient’s immune system and eradicate residual cancerous or malignant cells that are resistant to - or cannot be reach by - chemotherapy. Conventional TBI uses large parallel-opposed fields with manual placement of lead compensators to adjust for the varying thickness of a patient’s body. This dissertation proposes utilization of modern electronic compensation to more accurately deliver dose to TBI patients. To comprehensively evaluate electronic compensation for TBI, first a method is presented to simulate the conventional compensation technique within the treatment planning system (TPS) using a field-in-field (FIF) technique. Next, two different methods are introduced for generating an optimal influence for electronic compensation to deliver a total body dose. The initial technique consists of manually painting the optimal influence within each field based on isodose lines produced by uncompensated fields. For clinical feasibility, the process is then automated using computational methods, and the outcomes for code-generated optimal influence are explored. Dose–volume histograms (DVH) are computed for each of the three methods. The electronic compensation techniques with manually-painted influence and code-generated influence both produce a superior dose distribution with respect to conventional compensation. A quality assurance procedure for total body irradiation with electronic compensation is outlined in this text as well as a patient positioning protocol. Experimental verifications are presented using the MapCHECK phantom in the actual clinical setup and gafchromic film measurements within a RANDO phantom demonstrate the deliverability and ac-curacy of these plans. This work provides both the framework for clinical imple-mentation of electronic compensation for TBI and evidence that such a method is capable of more accurately delivering a total body dose compared to conventional TBI procedures."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Electronic Compensation to Deliver a Total Body Radiation Dose"]}]}],"canonical_facts":{"dc:contributor":["Wang, Zhou (Iris)","Radiology"],"dc:creator":["Tyson, Tara"],"dc:date":["2019-07-30T15:11:58Z","2019","2019-05-17 15:54:42"],"dc:description":["Ph.D.","Total body irradiation (TBI) is a radiation therapy technique used to suppress a patient’s immune system and eradicate residual cancerous or malignant cells that are resistant to - or cannot be reach by - chemotherapy. Conventional TBI uses large parallel-opposed fields with manual placement of lead compensators to adjust for the varying thickness of a patient’s body. This dissertation proposes utilization of modern electronic compensation to more accurately deliver dose to TBI patients. To comprehensively evaluate electronic compensation for TBI, first a method is presented to simulate the conventional compensation technique within the treatment planning system (TPS) using a field-in-field (FIF) technique. Next, two different methods are introduced for generating an optimal influence for electronic compensation to deliver a total body dose. The initial technique consists of manually painting the optimal influence within each field based on isodose lines produced by uncompensated fields. For clinical feasibility, the process is then automated using computational methods, and the outcomes for code-generated optimal influence are explored. Dose–volume histograms (DVH) are computed for each of the three methods. The electronic compensation techniques with manually-painted influence and code-generated influence both produce a superior dose distribution with respect to conventional compensation. A quality assurance procedure for total body irradiation with electronic compensation is outlined in this text as well as a patient positioning protocol. Experimental verifications are presented using the MapCHECK phantom in the actual clinical setup and gafchromic film measurements within a RANDO phantom demonstrate the deliverability and ac-curacy of these plans. This work provides both the framework for clinical imple-mentation of electronic compensation for TBI and evidence that such a method is capable of more accurately delivering a total body dose compared to conventional TBI procedures."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/80029"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["applied physics"],"dc:title":["Electronic Compensation to Deliver a Total Body Radiation Dose"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:23Z"}