{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79935"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79935","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Investigating the Phenotype of Amylin Receptor-Expressing Cells in the Ventral Tegmental Area","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Xie, Yibo; 0000-0002-6401-3383"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Mietlicki-Baase, Elizabeth","Exercise and Nutrition Sciences"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-07-30T15:11:14Z","date_published":"2019-07-30T15:11:14Z","updated_at":"2026-07-27T19:05:21Z","subjects":["nutrition","neurosciences","public health"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79935","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Mietlicki-Baase, Elizabeth","Exercise and Nutrition Sciences"]},{"key":"dc:creator","label":"Author","values":["Xie, Yibo; 0000-0002-6401-3383"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-07-30T15:11:14Z","2019","2019-05-14 00:00:31"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["nutrition","neurosciences","public health"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79935"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","The role of amylin in regulating energy balance through its ability to suppress food intake by increasing satiation makes it a promising therapeutic method for obesity. Calcitonin receptor (CTR) is the core component of the amylin receptor and activation of the amylin receptor in the ventral tegmental area (VTA), which is located in the dopamine reward pathway, reduces food intake. This study is designed to investigate the VTA cell types that express amylin receptors and the influence of sex and diet differences on VTA amylin receptor colocalization in male and female rats were maintained on chow or a palatable high-fat diet. Immunohistochemical analyses showed VTA CTR is highly co-localized with dopamine neruons and neuronal cells regardless of sex and diet (chow or high fat diet), but is not colocalized with astrocytes. Collectively, these results indicated that the phenotype of VTA cells expressing the amylin receptor is highly dopaminergic and neuronal."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Investigating the Phenotype of Amylin Receptor-Expressing Cells in the Ventral Tegmental Area"]}]}],"canonical_facts":{"dc:contributor":["Mietlicki-Baase, Elizabeth","Exercise and Nutrition Sciences"],"dc:creator":["Xie, Yibo; 0000-0002-6401-3383"],"dc:date":["2019-07-30T15:11:14Z","2019","2019-05-14 00:00:31"],"dc:description":["M.S.","The role of amylin in regulating energy balance through its ability to suppress food intake by increasing satiation makes it a promising therapeutic method for obesity. Calcitonin receptor (CTR) is the core component of the amylin receptor and activation of the amylin receptor in the ventral tegmental area (VTA), which is located in the dopamine reward pathway, reduces food intake. This study is designed to investigate the VTA cell types that express amylin receptors and the influence of sex and diet differences on VTA amylin receptor colocalization in male and female rats were maintained on chow or a palatable high-fat diet. Immunohistochemical analyses showed VTA CTR is highly co-localized with dopamine neruons and neuronal cells regardless of sex and diet (chow or high fat diet), but is not colocalized with astrocytes. Collectively, these results indicated that the phenotype of VTA cells expressing the amylin receptor is highly dopaminergic and neuronal."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79935"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["nutrition","neurosciences","public health"],"dc:title":["Investigating the Phenotype of Amylin Receptor-Expressing Cells in the Ventral Tegmental Area"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:21Z"}