{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79918"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79918","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Mechanomorphology of Colloidal Aggregates and Gels Regulates Cell Fate","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Yuan, Yuan; 0000-0002-9032-6842"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Sarkar, Debanjan","Biomedical Engineering"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-07-30T15:11:05Z","date_published":"2019-07-30T15:11:05Z","updated_at":"2026-07-27T19:05:21Z","subjects":["biomedical engineering"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79918","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Sarkar, Debanjan","Biomedical Engineering"]},{"key":"dc:creator","label":"Author","values":["Yuan, Yuan; 0000-0002-9032-6842"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-07-30T15:11:05Z","2019","2019-05-12 08:44:12"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["biomedical engineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79918"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Colloidal gels, unlike monolithic hydrogels, are formed by aggregation of submicron colloidal particles into self-similar space-filling networks due to attractive interparticle interactions. By altering the aggregation mechanism, the particles within the aggregated network of colloidal gels can be organized with distinct microstructure to impart definite spatial morphology. And the bulk elasticity of the colloidal gel can be scaled with particle fraction for a given microstructural morphology. Electrostatic interaction mediated aggregation of ionic colloidal particles can form three-dimensional gel via the electrolytes present in the dispersion media. The mode of aggregation can be varied by altering the electrolyte characteristics as well as by the ionic strength of the electrolytes. Thus, the microstructural morphology of these aggregates and gels are engineered with defined geometry and their mechanical properties are either independently or interdependently controlled by the particle fraction. As a result, the colloidal aggregates and gels, as three-dimensional artificial extra­cellular matrix, can provide tunable mechanomorphology to guide the spatial organization of cells during morphogenesis. Since cellular morphogenesis is essentially dependent on the local spatial constraints and elasticity of the three­dimensional matrix, it is imperative that the mechanomorphology of the colloidal gels can provide guidance to regulate cell fate. To achieve this, colloidal gels with different mechanomorphological characteristics were developed from cationic colloidal particles, where the colloids particles were developed from cationic polyurethanes (PU). Ionic polyurethanes, as synthetic material, provides a platform to develop ionic aqueous colloids which can be aggregated to form colloidal gels.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Mechanomorphology of Colloidal Aggregates and Gels Regulates Cell Fate"]}]}],"canonical_facts":{"dc:contributor":["Sarkar, Debanjan","Biomedical Engineering"],"dc:creator":["Yuan, Yuan; 0000-0002-9032-6842"],"dc:date":["2019-07-30T15:11:05Z","2019","2019-05-12 08:44:12"],"dc:description":["Ph.D.","Colloidal gels, unlike monolithic hydrogels, are formed by aggregation of submicron colloidal particles into self-similar space-filling networks due to attractive interparticle interactions. By altering the aggregation mechanism, the particles within the aggregated network of colloidal gels can be organized with distinct microstructure to impart definite spatial morphology. And the bulk elasticity of the colloidal gel can be scaled with particle fraction for a given microstructural morphology. Electrostatic interaction mediated aggregation of ionic colloidal particles can form three-dimensional gel via the electrolytes present in the dispersion media. The mode of aggregation can be varied by altering the electrolyte characteristics as well as by the ionic strength of the electrolytes. Thus, the microstructural morphology of these aggregates and gels are engineered with defined geometry and their mechanical properties are either independently or interdependently controlled by the particle fraction. As a result, the colloidal aggregates and gels, as three-dimensional artificial extra­cellular matrix, can provide tunable mechanomorphology to guide the spatial organization of cells during morphogenesis. Since cellular morphogenesis is essentially dependent on the local spatial constraints and elasticity of the three­dimensional matrix, it is imperative that the mechanomorphology of the colloidal gels can provide guidance to regulate cell fate. To achieve this, colloidal gels with different mechanomorphological characteristics were developed from cationic colloidal particles, where the colloids particles were developed from cationic polyurethanes (PU). Ionic polyurethanes, as synthetic material, provides a platform to develop ionic aqueous colloids which can be aggregated to form colloidal gels.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79918"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["biomedical engineering"],"dc:title":["Mechanomorphology of Colloidal Aggregates and Gels Regulates Cell Fate"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:21Z"}