{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79894"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79894","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Development and Applications of Porphyrin-Phospholipid Liposomes","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Carter, Kevin"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Lovell, Jonathan","Biomedical Engineering"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-07-30T15:10:49Z","date_published":"2019-07-30T15:10:49Z","updated_at":"2026-07-27T19:05:19Z","subjects":["biomedical engineering"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79894","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Lovell, Jonathan","Biomedical Engineering"]},{"key":"dc:creator","label":"Author","values":["Carter, Kevin"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-07-30T15:10:49Z","2019","2019-05-06 17:18:40"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["biomedical engineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79894"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Small-molecule cancer therapeutics have traditionally had limited selectivity between targeted tumor cells and tissue, and healthy non-target tissues, often leading to significant side effects limiting the efficacy of the such therapies. Nanoparticle based have demonstrated the ability to improve the efficacy of these compounds by favorably enhancing their pharmacokinetics and biodistribution. However, nanoparticle based systems are often limited in efficacy by poor tumor drug uptake and bioavailability of the drugs. Stimuli based drug delivery systems have the ability to overcome such limitations and improve the therapeutic efficacy of nanoparticle drug delivery systems. This thesis focuses on the development and applications of Porphyrin-Phospholipid (PoP) Liposomes. Chapter 1 introduces the concept of triggered drug release and the various approaches used with liposome based drug delivery systems. Chapter 2 describes the initial development of PoP liposomes and the first instance of using PoP liposomes to stably entrap and release cargo using light as a stimuli as well as preliminary in vivo anti-tumor and biodistribution data. Chapter 3 describes the optimization of doxorubicin loaded PoP liposomes with particular focus on improving serum stability and blood circulation time. Chapter 4 describes the use of metal chelation to alter the light release properties and efficacy of mitoxantrone loaded PoP liposomes. Chapter 5 compares differences in the drug loading and stability of doxorubicin and irinotecan in PoP liposomes. Chapter 6 describes in vitro blood interactions, pharmacokinetics, the dependence of drug delivery on light Propagation, and phototoxicity and dose toxicity of the doxorubicin loaded PoP liposomes described in chapter 3. Chapter 7 describes a brief discussion of PoP liposomes and provides some future directions of the technology.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Development and Applications of Porphyrin-Phospholipid Liposomes"]}]}],"canonical_facts":{"dc:contributor":["Lovell, Jonathan","Biomedical Engineering"],"dc:creator":["Carter, Kevin"],"dc:date":["2019-07-30T15:10:49Z","2019","2019-05-06 17:18:40"],"dc:description":["Ph.D.","Small-molecule cancer therapeutics have traditionally had limited selectivity between targeted tumor cells and tissue, and healthy non-target tissues, often leading to significant side effects limiting the efficacy of the such therapies. Nanoparticle based have demonstrated the ability to improve the efficacy of these compounds by favorably enhancing their pharmacokinetics and biodistribution. However, nanoparticle based systems are often limited in efficacy by poor tumor drug uptake and bioavailability of the drugs. Stimuli based drug delivery systems have the ability to overcome such limitations and improve the therapeutic efficacy of nanoparticle drug delivery systems. This thesis focuses on the development and applications of Porphyrin-Phospholipid (PoP) Liposomes. Chapter 1 introduces the concept of triggered drug release and the various approaches used with liposome based drug delivery systems. Chapter 2 describes the initial development of PoP liposomes and the first instance of using PoP liposomes to stably entrap and release cargo using light as a stimuli as well as preliminary in vivo anti-tumor and biodistribution data. Chapter 3 describes the optimization of doxorubicin loaded PoP liposomes with particular focus on improving serum stability and blood circulation time. Chapter 4 describes the use of metal chelation to alter the light release properties and efficacy of mitoxantrone loaded PoP liposomes. Chapter 5 compares differences in the drug loading and stability of doxorubicin and irinotecan in PoP liposomes. Chapter 6 describes in vitro blood interactions, pharmacokinetics, the dependence of drug delivery on light Propagation, and phototoxicity and dose toxicity of the doxorubicin loaded PoP liposomes described in chapter 3. Chapter 7 describes a brief discussion of PoP liposomes and provides some future directions of the technology.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79894"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["biomedical engineering"],"dc:title":["Development and Applications of Porphyrin-Phospholipid Liposomes"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:19Z"}