{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79850"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79850","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Myeloid-Derived Suppressor Cells Negatively Regulate T Cell Trafficking as a Novel Mechanism of Immune Evasion","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Ku, Amy"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Evans, Sharon","Roswell Park"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-07-30T15:10:28Z","date_published":"2019-07-30T15:10:28Z","updated_at":"2026-07-27T19:05:19Z","subjects":["immunology","microbiology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79850","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Evans, Sharon","Roswell Park"]},{"key":"dc:creator","label":"Author","values":["Ku, Amy"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-07-30T15:10:28Z","2019"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation","Text"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["immunology","microbiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79850"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Myeloid-derived suppressor cells (MDSC) are potent immunomodulatory cells that play an extensive role in cancer progression and immune evasion. The prevailing view is that MDSC-mediated immunosuppression is restricted to specific anatomical sites where these cells co-mingle with T lymphocytes. Specifically, MDSC-mediated suppression of effector T cell function has been well documented and characterized within splenic reservoirs and within tumor tissues where accumulating MDSC are in close contact with T lymphocytes. However, the capacity of tumor-induced MDSC to limit T cell infiltration into the two critical microenvironments for antitumor immunity, i.e., lymph nodes (LN) and tumors, remains understudied. Regional LN are the major lines of defense against cancer and serve as hubs for the generation of adaptive immune responses and durable immunological memory. A rate-limiting step for immunological surveillance involves the efficient delivery of naïve T cells across high endothelial venules (HEV) which are the major vascular gateways for entry of blood-borne lymphocytes into LN. Previous reports have shown that peripheral MDSC from tumor-bearing mice reduce the expression of the LN homing receptor L-selectin on naïve CD4+ and CD8+ T lymphocytes, raising fundamental questions about the mechanisms governing this down regulation and its biological relevance for the generation of antitumor adaptive immunity. Here, we show that MDSC within the spleen and, unexpectedly, in the blood execute far-reaching immune suppression in a cancer setting by reducing expression of the L-selectin homing receptor on both naïve T or B cells.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Myeloid-Derived Suppressor Cells Negatively Regulate T Cell Trafficking as a Novel Mechanism of Immune Evasion"]}]}],"canonical_facts":{"dc:contributor":["Evans, Sharon","Roswell Park"],"dc:creator":["Ku, Amy"],"dc:date":["2019-07-30T15:10:28Z","2019"],"dc:description":["Ph.D.","Myeloid-derived suppressor cells (MDSC) are potent immunomodulatory cells that play an extensive role in cancer progression and immune evasion. The prevailing view is that MDSC-mediated immunosuppression is restricted to specific anatomical sites where these cells co-mingle with T lymphocytes. Specifically, MDSC-mediated suppression of effector T cell function has been well documented and characterized within splenic reservoirs and within tumor tissues where accumulating MDSC are in close contact with T lymphocytes. However, the capacity of tumor-induced MDSC to limit T cell infiltration into the two critical microenvironments for antitumor immunity, i.e., lymph nodes (LN) and tumors, remains understudied. Regional LN are the major lines of defense against cancer and serve as hubs for the generation of adaptive immune responses and durable immunological memory. A rate-limiting step for immunological surveillance involves the efficient delivery of naïve T cells across high endothelial venules (HEV) which are the major vascular gateways for entry of blood-borne lymphocytes into LN. Previous reports have shown that peripheral MDSC from tumor-bearing mice reduce the expression of the LN homing receptor L-selectin on naïve CD4+ and CD8+ T lymphocytes, raising fundamental questions about the mechanisms governing this down regulation and its biological relevance for the generation of antitumor adaptive immunity. Here, we show that MDSC within the spleen and, unexpectedly, in the blood execute far-reaching immune suppression in a cancer setting by reducing expression of the L-selectin homing receptor on both naïve T or B cells.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79850"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["immunology","microbiology"],"dc:title":["Myeloid-Derived Suppressor Cells Negatively Regulate T Cell Trafficking as a Novel Mechanism of Immune Evasion"],"dc:type":["Dissertation","Text"]},"updated_at":"2026-07-27T19:05:19Z"}