{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79839"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79839","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"A Study of Structure and Function at Neurotransmitter Binding Sites of Nicotinic Receptors","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Tripathy, Sushree; 0000-0001-9586-8969"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Zheng, Wenjun","Physics"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-07-29T19:44:27Z","date_published":"2019-07-29T19:44:27Z","updated_at":"2026-07-27T19:05:19Z","subjects":["biophysics","biochemistry","physiology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79839","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Zheng, Wenjun","Physics"]},{"key":"dc:creator","label":"Author","values":["Tripathy, Sushree; 0000-0001-9586-8969"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-07-29T19:44:27Z","2019","2019-05-07 11:58:32"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["biophysics","biochemistry","physiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79839"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","In 1961, Jacques Monod said, “I think I have discovered the second secret of life!”. This popular story was about “allosteric regulation”, which is apparently the biochemical alternative to the model of gene action (“first secret of life”) (Creager and Gaudillière 1996). A few years later, Monod, Wyman and Changeux (MWC) presented a beautifully simple model for the function of “allosteric proteins” in 1965 (Monod, Wyman et al. 1965). This model is the basis of my dissertation. The focus of this thesis is a specific class of allosteric proteins known as nicotinic acetylcholine receptors (nAChRs). Our target is to understand the structural correlate of neurotransmitter binding affinity using computational simulations."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["A Study of Structure and Function at Neurotransmitter Binding Sites of Nicotinic Receptors"]}]}],"canonical_facts":{"dc:contributor":["Zheng, Wenjun","Physics"],"dc:creator":["Tripathy, Sushree; 0000-0001-9586-8969"],"dc:date":["2019-07-29T19:44:27Z","2019","2019-05-07 11:58:32"],"dc:description":["Ph.D.","In 1961, Jacques Monod said, “I think I have discovered the second secret of life!”. This popular story was about “allosteric regulation”, which is apparently the biochemical alternative to the model of gene action (“first secret of life”) (Creager and Gaudillière 1996). A few years later, Monod, Wyman and Changeux (MWC) presented a beautifully simple model for the function of “allosteric proteins” in 1965 (Monod, Wyman et al. 1965). This model is the basis of my dissertation. The focus of this thesis is a specific class of allosteric proteins known as nicotinic acetylcholine receptors (nAChRs). Our target is to understand the structural correlate of neurotransmitter binding affinity using computational simulations."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79839"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["biophysics","biochemistry","physiology"],"dc:title":["A Study of Structure and Function at Neurotransmitter Binding Sites of Nicotinic Receptors"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:19Z"}