{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79820"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79820","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Elucidating the Pharmacokinetics and Pharmacodynamics of Oxidative Phosphorylation Uncouplers for the Treatment of Obesity","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Meyer, Lyndsey; 0000-0001-7676-6473"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Shah, Dhaval","Pharmaceutical Sciences"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-07-26T20:35:14Z","date_published":"2019-07-26T20:35:14Z","updated_at":"2026-07-27T19:05:19Z","subjects":["pharmaceutical sciences"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79820","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Shah, Dhaval","Pharmaceutical Sciences"]},{"key":"dc:creator","label":"Author","values":["Meyer, Lyndsey; 0000-0001-7676-6473"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-07-26T20:35:14Z","2019","2019-04-30 21:47:05"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["pharmaceutical sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79820"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Obesity continues to plague the population of the United States at an epidemic proportion. As many as 1 in 3 people in US are considered obese, and the current clinical treatment options are limited. The medical costs associated with the treatment of obesity and comorbidities are staggering, and the lack of viable treatment options increases the risks for more serious diseases like type II diabetes, certain types of cancer, and cardiovascular disease. In this dissertation, we have explored pharmacokinetics (PK) and pharmacodynamics (PD) of the once popular weight loss drug 2,4-dinitrophenol (DNP) to evaluate its potential as an anti-obesity agent. We hypothesize that targeting an oxidative phosphorylation uncoupler (uncoupler) like DNP to adipose tissue may give rise to enhanced fat ablation without the unwanted side-effects of hyperthermia. To accomplish this goal, we investigated exposure-response relationships of DNP at multiple levels (i.e. cellular, tissue, and whole-body level)."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Elucidating the Pharmacokinetics and Pharmacodynamics of Oxidative Phosphorylation Uncouplers for the Treatment of Obesity"]}]}],"canonical_facts":{"dc:contributor":["Shah, Dhaval","Pharmaceutical Sciences"],"dc:creator":["Meyer, Lyndsey; 0000-0001-7676-6473"],"dc:date":["2019-07-26T20:35:14Z","2019","2019-04-30 21:47:05"],"dc:description":["Ph.D.","Obesity continues to plague the population of the United States at an epidemic proportion. As many as 1 in 3 people in US are considered obese, and the current clinical treatment options are limited. The medical costs associated with the treatment of obesity and comorbidities are staggering, and the lack of viable treatment options increases the risks for more serious diseases like type II diabetes, certain types of cancer, and cardiovascular disease. In this dissertation, we have explored pharmacokinetics (PK) and pharmacodynamics (PD) of the once popular weight loss drug 2,4-dinitrophenol (DNP) to evaluate its potential as an anti-obesity agent. We hypothesize that targeting an oxidative phosphorylation uncoupler (uncoupler) like DNP to adipose tissue may give rise to enhanced fat ablation without the unwanted side-effects of hyperthermia. To accomplish this goal, we investigated exposure-response relationships of DNP at multiple levels (i.e. cellular, tissue, and whole-body level)."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79820"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["pharmaceutical sciences"],"dc:title":["Elucidating the Pharmacokinetics and Pharmacodynamics of Oxidative Phosphorylation Uncouplers for the Treatment of Obesity"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:19Z"}